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  2. DNAJC15 - DnaJ heat shock protein family (Hsp40) member C15 Gene

DNAJC15 - DnaJ heat shock protein family (Hsp40) member C15 Gene

中文名称:DnaJ 热休克蛋白家族 (Hsp40) 成员 C15

种属: Homo sapiens

同用名: MCJ; HSD18; DNAJD1

基因 ID: 29103 | 基因类型: protein coding

关于 DNAJC15

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:43,023,586-43,114,213 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 13.6), small intestine (RPKM 12.6) and 24 other tissues.

功能概要

预测启用 ATPase 激活剂活动。预测参与将蛋白质导入线粒体基质。预计在几个过程的上游或内部起作用,包括细胞对饥饿的反应;线粒体电子传递的负调节,NADH 到泛醌;和含蛋白质的复合物组装的负调节。预测位于线粒体内膜。预测是 PAM 复合体的一部分,Tim23 相关的进口电机。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. [provided by Alliance of Genome Resources, Apr 2022]

DNAJC15 基因产物(1)

mRNA Protein Name
NM_013238.3 NP_037370.2 dnaJ homolog subfamily C member 15
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23263864 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DNAJC15 蛋白结构

DnaJ

DnaJ: DnaJ domain (100 - 149)

  • 0
  • 100
  • 150 a.a.
蛋白主名 其他名称

dnaJ homolog subfamily C member 15

DNAJ domain-containing

DNAJC15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DNAJC15 Q9Y5T4 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra DNAJC15 Q9Y5T4 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra DNAJC15 Q9Y5T4 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra DNAJC15 Q9Y5T4 PAM16 Homo sapiens Q9Y3D7
Anti Tag CoIP
33961781
Intra DNAJC15 Q9Y5T4 PAM16 Homo sapiens Q9Y3D7
Anti Bait CoIP
23263864
Intra DNAJC15 Q9Y5T4 PAM16 Homo sapiens Q9Y3D7
Pull Down
23263864
Intra DNAJC15 Q9Y5T4 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra DNAJC15 Q9Y5T4 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus DNAJC15 VGNC VGNC:53812
Felis catus DNAJC15 VGNC VGNC:102185
Rattus norvegicus DNAJC15 RGD RGD:1307154
Mus musculus DNAJC15 MGD MGI:1913398
Macaca mulatta DNAJC15 VGNC VGNC:106258