UHRF1 - ubiquitin like with PHD and ring finger domains 1 Gene

中文名称：泛素样 PHD 和无名指结构域 1

种属: Homo sapiens

同用名: Np95; hNP95; ICBP90; RNF106; TDRD22; hUHRF1; huNp95

基因 ID: 29128 | 基因类型: protein coding

关于 UHRF1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,903,080-4,962,154 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 7.7), lymph node (RPKM 6.3) and 14 other tissues.

功能概要

该基因编码环指型 E3 泛素连接酶亚家族的成员。该蛋白质与特定的 DNA 序列结合，并募集组蛋白脱乙酰酶来调节基因表达。其表达在 G1 晚期达到峰值，并在细胞周期的 G2 和 M 期持续。它通过调节拓扑异构酶 IIalpha 和视网膜母细胞瘤基因表达在 G1/S 转换中发挥重要作用，并在 p53 依赖性 DNA 损伤检查点发挥作用。它被认为是整合表观遗传信息的中枢蛋白。该基因在多种癌症中上调，因此被认为是治疗靶点。已发现该基因编码不同异构体的多个转录变体。 12 号染色体上存在一个相关的假基因。[RefSeq 提供，2014 年 2 月]

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating Topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

UHRF1 基因产物(5)

mRNA	Protein	Name
NM_001048201.3	NP_001041666.1	E3 ubiquitin-protein ligase UHRF1 isoform 1
NM_001290050.2	NP_001276979.1	E3 ubiquitin-protein ligase UHRF1 isoform 1
NM_001290051.2	NP_001276980.1	E3 ubiquitin-protein ligase UHRF1 isoform 1
NM_001290052.2	NP_001276981.1	E3 ubiquitin-protein ligase UHRF1 isoform 1
NM_013282.5	NP_037414.3	E3 ubiquitin-protein ligase UHRF1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	10646863	GOA
enables hemi-methylated DNA-binding	IDA IDA: 通过直接分析推断	17673620	GOA
enables histone binding	IDA IDA: 通过直接分析推断	21777816	GOA
enables methyl-CpG binding	IDA IDA: 通过直接分析推断	15361834	GOA
enables methylated histone binding	IDA IDA: 通过直接分析推断	17967883	GOA
enables nucleic acid binding	EXP EXP: 通过实验结果推断	18772889	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15361834	GOA
enables ubiquitin protein ligase activity	IDA IDA: 通过直接分析推断	37728657	GOA
enables ubiquitin-protein transferase activity	IDA IDA: 通过直接分析推断	17967883	GOA
enables zinc ion binding	IDA IDA: 通过直接分析推断	21777816	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in heterochromatin formation	IDA IDA: 通过直接分析推断	17967883	GOA
involved in mitotic spindle assembly	IDA IDA: 通过直接分析推断	37728657	GOA
involved in negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: 通过突变表型推断	17673620	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	21777816	GOA
involved in positive regulation of protein metabolic process	IDA IDA: 通过直接分析推断	10646863	GOA
involved in protein autoubiquitination	IDA IDA: 通过直接分析推断	21745816	GOA
involved in regulation of epithelial cell proliferation	IMP IMP: 通过突变表型推断	15361834	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: 通过直接分析推断	22945642	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromatin	IDA IDA: 通过直接分析推断	17673620	GOA
located in euchromatin	IDA IDA: 通过直接分析推断	21777816	GOA
located in heterochromatin	IDA IDA: 通过直接分析推断	17967883	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10646863	GOA
located in replication fork	IDA IDA: 通过直接分析推断	17673620	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

E3 ubiquitin-protein ligase UHRF1

RING finger protein 106

UHRF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	UHRF1	Q96T88	DNMT1	Homo sapiens	P26358	Pull Down	17934516
种属内	UHRF1	Q96T88	DNMT1	Homo sapiens	P26358	Anti Bait CoIP	17934516
种属内	UHRF1	Q96T88	DNMT1	Homo sapiens	P26358	Confocal	17934516
种属内	UHRF1	Q96T88	DNMT1	Homo sapiens	P26358	Anti Tag CoIP	19798101
种属内	UHRF1	Q96T88	DNMT1	Homo sapiens	P26358	Y2H	17934516
种属内	UHRF1	Q96T88	DNMT3B	Homo sapiens	Q9UBC3	Fluorescence	19798101
种属内	UHRF1	Q96T88	DNMT3B	Homo sapiens	Q9UBC3	Anti Bait CoIP	19798101
种属内	UHRF1	Q96T88	DNMT3B	Homo sapiens	Q9UBC3	Anti Tag CoIP	19798101
种属内	UHRF1	Q96T88	DNMT3A	Homo sapiens	Q9Y6K1	Anti Bait CoIP	19798101
种属内	UHRF1	Q96T88	DNMT3A	Homo sapiens	Q9Y6K1	Anti Tag CoIP	19798101
种属内	UHRF1	Q96T88	DNMT3A	Homo sapiens	Q9Y6K1	Fluorescence	19798101

种属间: 跨种属相互作用 种属内: 同种属相互作用

UHRF1 抗体

目录号	产品名	应用	反应物种
HY-P81313	UHRF1 Antibody (YA1056)	WB	Human, Mouse
HY-P81313A	UHRF1 Antibody (YA1057)	IHC-P	Human

关联疾病

疾病名称

别名

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant

Autosomal Dominant Cerebellar Ataxia, Deafness And Narcolepsy	ADCADN
Autosomal Dominant Cerebellar Ataxia, Deafness, And Narcolepsy	Adca-Dn Syndrome
Autosomal Dominant Cerebellar Ataxia-Deafness-Narcolepsy Syndrome	Adca-Dn
Autosomal Dominant Cerebellar Ataxia-Hearing Loss-Narcolepsy Syndrome	Ataxia, Cerebellar, Deafness, And Narcolepsy, Autosomal Dominant

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Oligospermia

Oculoauricular Syndrome

OCACS	Schorderet-Munier-Franceschetti Syndrome
Microphthalmia, Microcornea, Anterior Segment Dysgenesis, Cataract, Ocular Coloboma, Retinal Pigment Epithelium Abnormalities, Rod-Cone Dystrophy, And Anomalies Of The External Ear	Oculoauricular Syndrome, Schorderet Type
Oculo-Auricular Syndrome

Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

Icf Syndrome	Immunodeficiency Syndrome, Variable
Ciid	Centromeric Instability, Immunodeficiency Syndrome
Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16	Icf

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Neuropathy, Hereditary Sensory, Type Ie

HSN1E	Hsn Ie
Hereditary Sensory Neuropathy Type 1e	Hereditary Sensory Neuropathy Type Ie
Hsan 1	Neuropathy, Hereditary Sensory, With Hearing Loss And Dementia
Hereditary Sensory Neuropathy Type 1	Hsn1
Hereditary Sensory And Autonomic Neuropathy Type 1	Neuropathy Hereditary Sensory And Autonomic Type 1
Neuropathy Hereditary Sensory Radicular, Autosomal Dominant	Neuropathy, Hereditary Sensory, 1e
Neuropathy Hereditary Sensory With Hearing Loss And Dementia	Neuropathy, Hereditary Sensory, Type I
Neuropathy, Sensory, Hereditary, Type Ie	Hereditary Sensory And Autonomic Neuropathy Type Ie
Hereditary Sensory Autonomic Neuropathy, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-125292	NV03		98.82%	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	UHRF1	MGD	MGI:1338889
Macaca mulatta	UHRF1	VGNC	VGNC:78713
Bos taurus	UHRF1	VGNC	VGNC:36654
Rattus norvegicus	UHRF1	RGD	RGD:1595855
Canis familiaris	UHRF1	VGNC	VGNC:48123
Others	UHRF1	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

UHRF1 - ubiquitin like with PHD and ring finger domains 1 Gene

关于 UHRF1

功能概要

UHRF1 基因产物(5)

UHRF1 蛋白互作信息

UHRF1 抗体

关联疾病

直系同源

热门区域

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UHRF1 - ubiquitin like with PHD and ring finger domains 1 Gene

关于 UHRF1

功能概要

UHRF1 基因产物(5)

UHRF1 蛋白互作信息

UHRF1 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

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T

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