1. Gene
  2. Jag1 - jagged canonical Notch ligand 1 Gene

Jag1 - jagged canonical Notch ligand 1 Gene

种属: Rattus norvegicus

基因 ID: 29146 | 基因类型: protein coding

关于 Jag1

功能概要

Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Located in plasma membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Jag1 基因产物(1)

mRNA Protein Name
NM_019147.2 NP_062020.2 protein jagged-1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
28089369 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
20145246 RGD
enables receptor ligand activity IDA
IDA: 通过直接分析推断
7697721 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Notch signaling pathway IDA
IDA: 通过直接分析推断
7697721 RGD
involved in Notch signaling pathway IMP
IMP: 通过突变表型推断
15057910 RGD
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
15057910 RGD
involved in inner ear auditory receptor cell differentiation IMP
IMP: 通过突变表型推断
10887092 RGD
involved in negative regulation of cell differentiation IDA
IDA: 通过直接分析推断
7697721 RGD
involved in positive regulation of cardiac epithelial to mesenchymal transition IGI
IGI: 通过遗传相互作用推断
20951801 RGD
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
20951801 RGD
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15057910 RGD
involved in wound healing IEP
IEP: 通过表达模式推断
11549580 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

protein jagged-1

jagged 1

Jag1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Jag1 Q63722 LRP1 Homo sapiens Q07954
Anti Tag CoIP
20472562
Cross Jag1 Q63722 Thbs2 Mus musculus Q03350
Anti Tag CoIP
20472562
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Jag1 NCBI NCBI:182
Mus musculus Jag1 NCBI NCBI:16449