1. Gene
  2. Jag1 - jagged canonical Notch ligand 1 Gene

Jag1 - jagged canonical Notch ligand 1 Gene

种属: Rattus norvegicus

基因 ID: 29146 | 基因类型: protein coding

关于 Jag1

功能概要

Enables Notch binding activity and receptor ligand activity. Involved in several processes, including animal organ regeneration; inner ear auditory receptor cell differentiation; and positive regulation of cardiac epithelial to mesenchymal transition. Located in plasma membrane. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Jag1 基因产物(1)

mRNA Protein Name
NM_019147.2 NP_062020.2 protein jagged-1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
28089369 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
20145246 RGD
enables receptor ligand activity IDA
IDA: 通过直接分析推断
7697721 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Notch signaling pathway IDA
IDA: 通过直接分析推断
7697721 RGD
involved in Notch signaling pathway IMP
IMP: 通过突变表型推断
15057910 RGD
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
15057910 RGD
involved in inner ear auditory receptor cell differentiation IMP
IMP: 通过突变表型推断
10887092 RGD
involved in negative regulation of cell differentiation IDA
IDA: 通过直接分析推断
7697721 RGD
involved in positive regulation of cardiac epithelial to mesenchymal transition IGI
IGI: 通过遗传相互作用推断
20951801 RGD
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
20951801 RGD
involved in regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15057910 RGD
involved in wound healing IEP
IEP: 通过表达模式推断
11549580 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

protein jagged-1

jagged 1

Jag1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Jag1 Q63722 LRP1 Homo sapiens Q07954 20472562
种属间
Jag1 Q63722 Thbs2 Mus musculus Q03350 20472562
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Jag1 NCBI NCBI:182
Mus musculus Jag1 NCBI NCBI:16449