2. Gene
  3. Fto - FTO, alpha-ketoglutarate dependent dioxygenase Gene

Fto - FTO, alpha-ketoglutarate dependent dioxygenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：FTO， α-酮戊二酸依赖性双加氧酶

种属: Rattus norvegicus

同用名: RGD1305121

基因 ID: 291905 | 基因类型: protein coding

关于 Fto

Primary_assembly 19: 15,349,696-15,692,083 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 202 orthologues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 136.3), Kidney (RPKM 111.9) and 9 other tissues.

功能概要

预测该基因编码的蛋白可实现 2-酮戊二酸依赖性双加氧酶活性和二价铁结合活性。预计参与多个过程，包括 mRNA 不稳定；核酸代谢过程；和调节呼吸系统过程。预测位于胞质溶胶中；核斑点；和质膜。该基因的人类直系同源物与肥胖有关。与人 FTO（FTO α-酮戊二酸依赖性双加氧酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Predicted to be involved in several processes, including mRNA destabilization; nucleic acid metabolic process; and regulation of respiratory system process. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Fto 基因产物(1)

mRNA Protein Name
NM_001039713.1 NP_001034802.1 alpha-ketoglutarate-dependent dioxygenase FTO
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heart development IEP
IEP: 通过表达模式推断
36426889 RGD
involved in negative regulation of eating behavior IMP
IMP: 通过突变表型推断
20098739 RGD
involved in osteoblast differentiation IMP
IMP: 通过突变表型推断
35006515 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
30835997 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
29890211 RGD
involved in regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
30835997 RGD
involved in response to bisphenol A IEP
IEP: 通过表达模式推断
35945320 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
28179100 RGD
involved in sensory perception of pain IMP
IMP: 通过突变表型推断
33829413 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Fto 蛋白结构

FTO_NTD

FTO_NTD: pfam12933 (35 - 321)

FTO_CTD

FTO_CTD: cl15176 (325 - 493)

  • 0
  • 100
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  • 400
  • 502 a.a.
蛋白主名 其他名称

alpha-ketoglutarate-dependent dioxygenase FTO

U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO

fat mass and obesity associated

fat mass and obesity-associated protein

m6A(m)-demethylase FTO

mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO

mRNA N(6)-methyladenosine demethylase FTO

protein fto

tRNA N1-methyl adenine demethylase FTO

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14280 Entacapone Inhibitor 99.97% 是
HY-B1320 Meclofenamic acid sodium Inhibitor 99.86% 否
HY-117275 Meclofenamic acid Inhibitor 98.60% 否
HY-117275A Meclofenamic acid sodium hydrate Inhibitor / 否
HY-14280R Entacapone (Standard) Inhibitor / 否
HY-14280A Entacapone sodium salt Inhibitor / 否
Pre-clinical Phase
生物活性分子 (27)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-127103 FB23-2 Inducer 99.93% 否
HY-137187 FB23 98.66% 否
HY-N6769 Radicicol Inhibitor 99.63% 否
HY-101082 N6,2′-O-Dimethyladenosine Inhibitor 99.93% 否
HY-151106 FTO-IN-8 Inhibitor 98.03% 否
HY-149334 ZLD115 Inhibitor 99.24% 否
HY-145238 FTO-IN-6 98.94% 否
HY-138843A FTO-IN-1 TFA 98.06% 否
HY-147011 FTO-IN-7 Inhibitor 99.22% 否
HY-132865 FTO-IN-3 99.79% 否
HY-RS05137 Fto Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W588293 3-Methylthymidine 99.68% 否
HY-117426 MO-I-500 Inhibitor 99.10% 否
HY-14280S Entacapone-d10 Inhibitor ≥98.0% 否
HY-RS05136 FTO Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-117275S Meclofenamic acid-d4 Inhibitor / 否
HY-117275S1 Meclofenamic acid-13C6 Inhibitor / 否
HY-132863 FTO-IN-2 / 否
HY-138843 FTO-IN-1 / 否
HY-139820 FTO-IN-4 / 否
HY-139821 FTO-IN-5 / 否
HY-156405 FTO-IN-10 / 否
HY-168483 FTO-IN-13 / 否
HY-N10340 Clausine E Inhibitor / 否
HY-RS05138 Fto Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W026109 FTO-IN-12 Inhibitor / 否
HY-131871 Ethyl LipotF Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fto NCBI NCBI:79068
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