CXCL2 - C-X-C motif chemokine ligand 2 Gene

中文名称：CXC 基序趋化因子配体 2

种属: Homo sapiens

同用名: GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a

基因 ID: 2920 | 基因类型: protein coding

关于 CXCL2

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:74,097,040-74,099,195 (from NCBI)

This gene has 3 transcripts (splice variants), 21 orthologues and 12 paralogues. Broad expression in liver (RPKM 52.2), gall bladder (RPKM 27.8) and 15 other tissues.

功能概要

这种抗菌基因是趋化因子超家族的一部分，该家族编码参与免疫调节和炎症过程的分泌蛋白。基于成熟肽的 N 末端半胱氨酸残基的排列，该超家族分为四个亚家族。这种趋化因子是 CXC 亚家族的成员，在炎症部位表达，可能抑制造血祖细胞增殖。[RefSeq 提供，2014 年 9 月]

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

CXCL2 基因产物(1)

mRNA	Protein	Name
NM_002089.4	NP_002080.1	C-X-C motif chemokine 2 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18275857	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	12949249	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	12949249	GOA
involved in response to molecule of bacterial origin	IDA IDA: 通过直接分析推断	19912257	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CXCL2 蛋白结构

IL8

0
100
107 a.a.

蛋白主名

其他名称

C-X-C motif chemokine 2

GRO2 oncogene

CXCL2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CXCL2	P19875	PF4	Homo sapiens	P02776	SPR	28381538
种属内	CXCL2	P19875	PF4	Homo sapiens	P02776	Filter Binding	28381538
种属内	CXCL2	P19875	CCL5	Homo sapiens	P13501	SPR	28381538
种属内	CXCL2	P19875	CCL5	Homo sapiens	P13501	Filter Binding	28381538
种属内	CXCL2	P19875	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
种属内	CXCL2	P19875	CXCL12	Homo sapiens	P48061	SPR	28381538

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CXCL2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7190	GRO-beta/CXCL2 Protein, Human	P19875 (A35-N107)	≥95%
HY-P700045AF	Animal-Free GRO-beta/CXCL2 Protein, Human (His)	P19875 (A35-N107)	≥95%

关联疾病

疾病名称

别名

Peritonitis

Retractile Mesenteritis	Sclerosing Mesenteritis
Acute Generalized Peritonitis	Primary Bacterial Peritonitis
Idiopathic Sclerosing Mesenteritis	Mesenteric Panniculitis
Peritoneal Retractile Mesenteritis	Liposclerotic Mesenteritis
Mesenteric Fibromatosis	Mesenteric Lipodystrophy
Mesenteric Lipogranuloma	Fibromatosis, Abdominal
Peritoneum Inflammation	Peritonitis Of Undetermined Cause
Peritonitis Of Unspecified Cause	Pelviperitonitis
Pelvic Peritonitis, Nos	Generalised Peritonitis Nos
Abdominal Peritonitis	Acute Idiopathic Peritonitis
Acute Lesser Sac Peritonitis	Acute Peritoneal Inflammation
Diffuse Peritonitis	Peritoneal Inflammation
Acute Primary Peritonitis	Pneumococcal Peritonitis

Acanthamoeba Keratitis

Pneumonia

Acute Pneumonia	Pneumonias
Infectious Pneumonia	Pn - [Pneumonia]
Lobar Pneumonia Nos	Multifocal Pneumonia
Orthostatic Pneumonia	Pneumonia Nos
Chronic Pneumonia Nos	Atypical Pneumonia
Passive Pneumonia	Purulent Pneumonia
Interstitial Lobar Pneumonia	Pneumonia, Unspecified
Pneumonia Due To Chlamydia	Pneumonia Due To Chlamydia Pneumoniae
Pneumonia Due To E. Coli	Escherichia Coli Lobar Pneumonia
Pneumonia Due To H. Influenzae	Pneumonia Due To Hemophilus Influenzae
Bronchopneumonia Due To H. Influenzae	Haemophilus Influenzae Lobar Pneumonia
Bronchopneumonia Due To Hemophilus Influenzae	Pseudomonal Pneumonia
Pseudomonas Pneumonia	Pseudomonas Lobar Pneumonia
Staphylococcal Pneumonia	Staphylococcus Pneumonia
Acute Staphylococcal Pneumonia	Staphylococcal Double Pneumonia
Staphylococcal Lobar Pneumonia	Staphylococcal Purulent Pneumonia
Staphylococcal Bronchopneumonia	Pneumococcal Pneumonia
Pneumococcus Pneumonia	Bronchopneumonia Due To S. Pneumoniae
Pneumococcal Lobar Pneumonia	Streptococcal Pneumoniae Pneumonia
Streptococcus Pneumoniae Lobar Pneumonia	Pyemic Pneumococcal Embolism With Pneumonia
Bronchopneumonia Due To Streptococcus Pneumoniae	Pneumonia Due To Streptococcus, Group B
Group B Streptococcal Pneumonia	Adenovirus Pneumonia
Adenoviral Pneumonia	Adenovirus Viral Pneumonia
Pneumonia Respiratory Syncytial Viral	Parainfluenza Viral Pneumonia
Parainfluenzal Pneumonia	Parainfluenza Virus Pneumonia
Human Metapneumovirus Pneumonia	Human Metapneumovirus Infection Resulting In Pneumonia
Pneumocystis Pneumonia	Plasma Cells Pneumonia

Meningoencephalitis

Acquired Toxoplasmal Meningoencephalitis	Meningoencephalitis Due To Acquired Toxoplasmosis
Meningoencephalitis Due To Toxoplasmosis	Toxoplasma Meningoencephalitis

Keratitis, Hereditary

Keratitis	Autosomal Dominant Keratitis
Hereditary Keratitis	Dominantly Inherited Keratitis
Keratitis Hereditary	KERH

Pyelonephritis

Colitis

Meningitis

Streptococcal Meningitis	Acute Streptococcal Meningitis
Staphylococcal Meningitis	Adenoviral Meningitis
Influenza Meningitis	Influenzal Meningitis
Meningitis Due To H. Influenzae	Cryptococcal Meningitis
Fungal Meningitis Due To Cryptococcus Neoformans	Cryptococcosis Meningitis
Cryptococcus Meningitis	Cryptococcal Meningoencephalitis
Meningitis Due To Cryptococcus	Mumps Virus Meningitis
Mumps Meningitis

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	纯度	是否罕见病
HY-B1322A	Amodiaquine	99.98%	否
HY-B1322	Amodiaquine dihydrochloride dihydrate	99.89%	否
HY-B1322B	Amodiaquine dihydrochloride	99.89%	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-B1322AS1	Amodiaquine-d10 hydrochloride		/	否
HY-RS03391	CXCL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CXCL2	RGD	RGD:70069
Mus musculus	CXCL2	NCBI	NCBI:20310
Others	CXCL2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CXCL2 - C-X-C motif chemokine ligand 2 Gene

关于 CXCL2

功能概要

CXCL2 基因产物(1)

CXCL2 蛋白结构

CXCL2 蛋白互作信息

重组 CXCL2 蛋白

关联疾病

直系同源

热门区域

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CXCL2 - C-X-C motif chemokine ligand 2 Gene

关于 CXCL2

功能概要

CXCL2 基因产物(1)

CXCL2 蛋白结构

CXCL2 蛋白互作信息

重组 CXCL2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z