2. Gene
  3. Lrp2 - LDL receptor related protein 2 Gene

Lrp2 - LDL receptor related protein 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29216 | 基因类型: protein coding

关于 Lrp2

功能概要

Enables several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including endocytic hemoglobin import into cell; positive regulation of transport; and response to vitamin D. Located in several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrp2 基因产物(1)

mRNA Protein Name
NM_030827.2 NP_110454.2 low-density lipoprotein receptor-related protein 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
21325834 RGD
enables hemoglobin binding IDA
IDA: 通过直接分析推断
11805171 RGD
enables hormone binding IPI
IPI: 通过物理相互作用推断
15131016 RGD
enables insulin-like growth factor I binding IDA
IDA: 通过直接分析推断
16306401 RGD
enables low-density lipoprotein particle receptor binding IPI
IPI: 通过物理相互作用推断
22349218 RGD
enables nuclear receptor binding IPI
IPI: 通过物理相互作用推断
16143106 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10769163 RGD
enables protein transporter activity IDA
IDA: 通过直接分析推断
16306401 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
21372499 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IMP
IMP: 通过突变表型推断
16306401 RGD
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
15266031 RGD
involved in cellular response to growth factor stimulus IMP
IMP: 通过突变表型推断
16306401 RGD
involved in chemoattraction of axon IMP
IMP: 通过突变表型推断
26598525 RGD
involved in endocytic hemoglobin import into cell IMP
IMP: 通过突变表型推断
11805171 RGD
involved in endocytosis IMP
IMP: 通过突变表型推断
15670845 RGD
involved in endosomal transport IMP
IMP: 通过突变表型推断
9039057 RGD
involved in metal ion transport IDA
IDA: 通过直接分析推断
15126248 RGD
involved in metanephric proximal tubule development IEP
IEP: 通过表达模式推断
30645697 RGD
involved in positive regulation of endocytosis IMP
IMP: 通过突变表型推断
10766831 RGD
involved in positive regulation of lipoprotein transport IMP
IMP: 通过突变表型推断
10766831 RGD
involved in protein import IMP
IMP: 通过突变表型推断
16128811 RGD
involved in receptor-mediated endocytosis IDA
IDA: 通过直接分析推断
11595644 RGD
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
8626514 RGD
involved in response to X-ray IDA
IDA: 通过直接分析推断
12121845 RGD
involved in response to leptin IMP
IMP: 通过突变表型推断
17324488 RGD
involved in response to retinoic acid IEP
IEP: 通过表达模式推断
9541123 RGD
involved in response to vitamin D IEP
IEP: 通过表达模式推断
9541123 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
15266031 RGD
involved in transcytosis IMP
IMP: 通过突变表型推断
14657389 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
10919857 RGD
located in axonal growth cone IDA
IDA: 通过直接分析推断
26598525 RGD
located in brush border IDA
IDA: 通过直接分析推断
11912251 RGD
located in brush border membrane IDA
IDA: 通过直接分析推断
6752952 RGD
located in cell surface IDA
IDA: 通过直接分析推断
10766831 RGD
located in endosome IDA
IDA: 通过直接分析推断
17063000 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
17063000 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
17324488 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
22349218 RGD
part of receptor complex IDA
IDA: 通过直接分析推断
19202329 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

low-density lipoprotein receptor-related protein 2

LRP-2

glycoprotein 330

gp330

low density lipoprotein-related protein 2

megalin

Lrp2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Lrp2 P98158 Dab2 Rattus norvegicus O88797
Anti Bait CoIP
10769163
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07797 LRP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lrp2 NCBI NCBI:4036
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