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  2. Acvr2a - activin A receptor type 2A Gene

Acvr2a - activin A receptor type 2A Gene

中文名称:激活素 A 受体 2A 型

种属: Rattus norvegicus

同用名: Acvr2; rActR-II

基因 ID: 29263 | 基因类型: protein coding

关于 Acvr2a

Primary_assembly 3: 33,205,523-33,289,968 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 8 phenotypes. Biased expression in Lung (RPKM 192.7), Brain (RPKM 161.5) and 9 other tissues.

功能概要

该基因编码的蛋白可启动激活素结合活性和抑制素结合活性。参与肾上腺发育;促卵泡激素分泌的正调节;和对有机物的反应。预测位于细胞表面和细胞质中。预计是激活素受体复合物和抑制素-β聚糖-ActRII 复合物的一部分。预计在质膜上有活性。该基因的人类直系同源物与结肠癌有关。与人类 ACVR2A(2A 型激活素 A 受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables activin binding activity and inhibin binding activity. Involved in adrenal gland development; positive regulation of follicle-stimulating hormone secretion; and response to organic substance. Predicted to be located in cell surface and cytoplasm. Predicted to be part of activin receptor complex and inhibin-betaglycan-ActRII complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a 基因产物(1)

mRNA Protein Name
NM_031571.3 NP_113759.2 activin receptor type-2A precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables activin binding IDA
IDA: 通过直接分析推断
12385827 RGD
enables inhibin binding IDA
IDA: 通过直接分析推断
12385827 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in SMAD protein signal transduction IMP
IMP: 通过突变表型推断
27769861 RGD
involved in adrenal gland development IEP
IEP: 通过表达模式推断
12844345 RGD
involved in autophagy IMP
IMP: 通过突变表型推断
27769861 RGD
involved in cellular response to oxygen-glucose deprivation IMP
IMP: 通过突变表型推断
27769861 RGD
involved in positive regulation of follicle-stimulating hormone secretion IMP
IMP: 通过突变表型推断
11861519 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Acvr2a 蛋白结构

Activin_recp

Activin_recp: pfam01064 (58 - 113)

STKc_ACVR2a

STKc_ACVR2a: cd14141 (203 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 521 a.a.
蛋白主名 其他名称

activin receptor type-2A

ACTR-IIA

activin A receptor, type IIA

activin receptor IIA

activin receptor type IIA

type II activin receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acvr2a NCBI NCBI:92
Mus musculus Acvr2a NCBI NCBI:11480