2. Gene
  3. Acvr2a - activin receptor IIA Gene

Acvr2a - activin receptor IIA Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：激活素受体 IIA

种属: Mus musculus

同用名: Acvr2; ActrIIa; TactrII

基因 ID: 11480 | 基因类型: protein coding

关于 Acvr2a

Chromosome 2: 48,704,121-48,793,281 forward strand.GRCm39:CM000995.3

This gene has 2 transcripts (splice variants), 275 orthologues, 11 paralogues and is associated with 45 phenotypes. Broad expression in CNS E18 (RPKM 16.6), whole brain E14.5 (RPKM 12.4) and 25 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 BMP 受体活性； PDZ 域绑定活动；和激活素结合活性。作用于多个过程的上游或内部，包括支持细胞增殖；交配;和胚胎骨骼系统发育。位于细胞表面。以多种结构表达，包括中枢神经系统；早孕;性腺;直觉;和感觉器官。用于研究 Weissenbacher-Zweymuller 综合征。该基因的人类直系同源物与结肠癌有关。与人类 ACVR2A（2A 型激活素 A 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including BMP Receptor activity; PDZ domain binding activity; and activin binding activity. Acts upstream of or within several processes, including Sertoli cell proliferation; copulation; and embryonic skeletal system development. Located in cell surface. Is expressed in several structures, including central nervous system; early conceptus; gonad; gut; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome. Human ortholog(s) of this gene implicated in colon Cancer. Orthologous to human ACVR2A (Activin A receptor type 2A). [provided by Alliance of Genome Resources, Apr 2022]

Acvr2a 基因产物(1)

mRNA Protein Name
NM_007396.4 NP_031422.3 activin receptor type-2A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BMP receptor activity IMP
IMP: 通过突变表型推断
26774823 MGI
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
16648306 MGI
enables activin binding IPI
IPI: 通过物理相互作用推断
1646080 MGI
enables activin receptor activity IDA
IDA: 通过直接分析推断
8395525 MGI
enables growth factor binding IMP
IMP: 通过突变表型推断
12414726 MGI
enables growth factor binding IPI
IPI: 通过物理相互作用推断
11459935 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8612709 MGI
enables inhibin binding IPI
IPI: 通过物理相互作用推断
7890768 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16648306 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within BMP signaling pathway IMP
IMP: 通过突变表型推断
17472960 MGI
involved in BMP signaling pathway IMP
IMP: 通过突变表型推断
26774823 MGI
acts upstream of or within Sertoli cell proliferation IMP
IMP: 通过突变表型推断
11416011 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
10452853 MGI
acts upstream of or within determination of left/right symmetry IGI
IGI: 通过遗传相互作用推断
16991118 MGI
acts upstream of or within embryonic skeletal system development IMP
IMP: 通过突变表型推断
7885474 MGI
acts upstream of or within gastrulation with mouth forming second IGI
IGI: 通过遗传相互作用推断
10452853 MGI
acts upstream of or within male gonad development IMP
IMP: 通过突变表型推断
7885474 MGI
acts upstream of or within mesoderm development IGI
IGI: 通过遗传相互作用推断
10452853 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: 通过遗传相互作用推断
16330774 MGI
acts upstream of or within penile erection IMP
IMP: 通过突变表型推断
16093358 MGI
acts upstream of or within regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
16093358 MGI
acts upstream of or within regulation of signal transduction IDA
IDA: 通过直接分析推断
17936261 MGI
acts upstream of or within sperm ejaculation IMP
IMP: 通过突变表型推断
16093358 MGI
acts upstream of or within spermatogenesis IGI
IGI: 通过遗传相互作用推断
11459797 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
16648306 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
8395525 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Acvr2a 蛋白结构

Activin_recp

Activin_recp: pfam01064 (58 - 113)

STKc_ACVR2a

STKc_ACVR2a: cd14141 (195 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 513 a.a.
蛋白主名 其他名称

activin receptor type-2A

ACTR-IIA

activin receptor type IIA

重组 Acvr2a 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75562 ACVR2A/Activin RIIA Protein, Mouse (HEK293, His-Fc) P27038 (M1-P134) ≥95%
HY-P75563 ACVR2A/Activin RIIA Protein, Mouse (HEK293, His) P27038 (A20-P134) ≥95%

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99590 Sotatercept 99.61% 否
Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99355 Bimagrumab Inhibitor 99.23% Phase 3

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Acvr2a NCBI NCBI:92
Rattus norvegicus Acvr2a NCBI NCBI:29263
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