2. Gene
  3. Npy1r - neuropeptide Y receptor Y1 Gene

Npy1r - neuropeptide Y receptor Y1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：神经肽 Y 受体 Y1

种属: Rattus norvegicus

同用名: NPY-1

基因 ID: 29358 | 基因类型: protein coding

关于 Npy1r

Primary_assembly 16: 23,037,789-23,046,759 reverse strand.mRatBN7.2:CM026989.1

This gene has 2 transcripts (splice variants), 145 orthologues, 50 paralogues and is associated with 19 phenotypes. Biased expression in Brain (RPKM 32.2), Adrenal (RPKM 2.1) and 8 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动胰多肽受体活性和肽YY受体活性。参与多个过程，包括细胞溶质钙离子浓度的负调节；蠕动;和血管收缩的正调节作用。位于多个细胞成分中，包括轴突；胞质溶胶；和突触小泡。用于研究焦虑症；儿童失神性癫痫；高血压;和精神抑郁症。肥胖和视觉性癫痫的生物标志物。与人类 NPY1R（神经肽 Y 受体 Y1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable pancreatic polypeptide receptor activity and peptide YY receptor activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; peristalsis; and positive regulation of vasoconstriction. Located in several cellular components, including axon; cytosol; and synaptic vesicle. Used to study anxiety disorder; childhood absence epilepsy; hypertension; and mental depression. Biomarker of obesity and visual epilepsy. Orthologous to human NPY1R (Neuropeptide Y Receptor Y1). [provided by Alliance of Genome Resources, Apr 2022]

Npy1r 基因产物(1)

mRNA Protein Name
NM_001113357.1 NP_001106828.1 neuropeptide Y receptor type 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
17143304 RGD
involved in negative regulation of hormone secretion IMP
IMP: 通过突变表型推断
10464394 RGD
involved in peristalsis IMP
IMP: 通过突变表型推断
12919938 RGD
involved in positive regulation of cholesterol biosynthetic process IMP
IMP: 通过突变表型推断
32976883 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
9802404 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: 通过实验结果推断
16026936 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
16026936 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: 通过实验结果推断
16026936 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
16026936 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
16904299 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
14726443 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
19267419 RGD
involved in response to morphine IMP
IMP: 通过突变表型推断
16766046 RGD
involved in synaptic signaling via neuropeptide EXP
EXP: 通过实验结果推断
11677256 RGD
involved in synaptic signaling via neuropeptide IDA
IDA: 通过直接分析推断
11677256 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
11891789 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
11677256 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11677256 RGD
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
29775703 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
11891789 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
11891789 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Npy1r 蛋白结构

7tmA_NPY1R

7tmA_NPY1R: cd15395 (39 - 329)

7tmA_NPY1R

7tmA_NPY1R: cd15395 (40 - 66)

7tmA_NPY1R

7tmA_NPY1R: cd15395 (73 - 98)

7tmA_NPY1R

7tmA_NPY1R: cd15395 (111 - 141)

7tmA_NPY1R

7tmA_NPY1R: cd15395 (152 - 173)

7tmA_NPY1R

7tmA_NPY1R: cd15395 (206 - 235)

7tmA_NPY1R

7tmA_NPY1R: cd15395 (254 - 284)

7tmA_NPY1R

7tmA_NPY1R: cd15395 (297 - 322)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
蛋白主名 其他名称

neuropeptide Y receptor type 1

FC5

NPY1-R

Neuropepetide Y1 Receptor

neuropeptide Y1 receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09511 NPY1R Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09512 Npy1r Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09513 Npy1r Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Npy1r NCBI NCBI:4886
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