1. Gene
  2. NPY1R - neuropeptide Y receptor Y1 Gene

NPY1R - neuropeptide Y receptor Y1 Gene

中文名称:神经肽 Y 受体 Y1

种属: Homo sapiens

同用名: NPYR; NPY1-R

基因 ID: 4886 | 基因类型: protein coding

关于 NPY1R

Cytogenetic location: 4q32.2 Genomic coordinates (GRCh38): 4:163,323,962-163,344,689 (from NCBI)

This gene has 7 transcripts (splice variants), 145 orthologues and 33 paralogues. Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues.

功能概要

该基因属于 G 蛋白偶联受体超家族。编码的跨膜蛋白介导神经肽 Y (NPY) (一种神经递质) 和肽 YY (PYY) (一种胃肠道激素) 的功能。编码的受体通过网格蛋白包被的凹坑进行快速激动剂诱导的内化,随后再循环回细胞膜。 Y1 受体的激活可能导致细胞内钙的动员和腺苷酸环化酶活性的抑制。[RefSeq 提供,2013 年 8 月]

This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of Adenylate Cyclase activity. [provided by RefSeq, Aug 2013]

NPY1R 基因产物(3)

mRNA Protein Name
NM_000909.6 NP_000900.1 neuropeptide Y receptor type 1
XM_005263031.5 XP_005263088.1 neuropeptide Y receptor type 1 isoform X1
XM_011532010.4 XP_011530312.1 neuropeptide Y receptor type 1 isoform X1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23597562 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
19593212 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NPY1R 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 320)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
蛋白主名 其他名称

neuropeptide Y receptor type 1

NPY1R 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NPY1R P25929 PYY Homo sapiens P10082
SPA
23597562
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pelvic Organ Prolapse

Rectal Prolapse

Pelvic Organ Prolapse, Susceptibility To

Pelvic Organ Prolapse, Susceptibility To, 1

Prolapse Of Vagina And Rectum

Vaginal Prolapse

Pelvic Organ Prolapse 1

Procidentia, Rectum

Prolapse Of Rectal Mucosa

Procidentia Of Rectum

Rectal Mucosa Prolapse

Rectum Prolapse

Procidentia Rectum

Rp - [Rectal Prolapse]

Male Proctocele

Male Rectocele

Proctoptosis

Female Genital Prolapse

Female Prolapse

Incompetence Of Pelvic Fundus

Relaxation Of Perineum

Deficiency Of Perineum

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NPY1R VGNC VGNC:75394
Felis catus NPY1R VGNC VGNC:78537
Rattus norvegicus NPY1R RGD RGD:3198
Mus musculus NPY1R MGD MGI:104963
Bos taurus NPY1R VGNC VGNC:32223
Canis familiaris NPY1R VGNC VGNC:43937
Others NPY1R NCBI