2. Gene
  3. S1pr2 - sphingosine-1-phosphate receptor 2 Gene

S1pr2 - sphingosine-1-phosphate receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：1-磷酸鞘氨醇受体 2

种属: Rattus norvegicus

同用名: Edg5; H218; GPCR18; Gpcr13; snGPCR18

基因 ID: 29415 | 基因类型: protein coding

关于 S1pr2

Primary_assembly 8: 19,502,627-19,523,574 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 192 orthologues, 18 paralogues and is associated with 6 phenotypes. Biased expression in Lung (RPKM 99.8), Heart (RPKM 92.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联肽受体活性。作用于 G 蛋白偶联受体信号通路的上游或内部；平滑肌细胞迁移的负调节；血管相关平滑肌细胞增殖的负调节。预计是膜的组成部分。预计在细胞质和质膜中有活性。该基因的人类直向同源基因与常染色体隐性非综合征性耳聋 68 相关。与人类 S1PR2（1-磷酸鞘氨醇受体 2）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled peptide receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

S1pr2 基因产物(1)

mRNA Protein Name
NM_017192.2 NP_058888.1 sphingosine 1-phosphate receptor 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled peptide receptor activity IDA
IDA: 通过直接分析推断
29453251 RGD
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
9409733 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
29453251 RGD
acts upstream of or within negative regulation of smooth muscle cell migration IGI
IGI: 通过遗传相互作用推断
29453251 RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
29453251 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S1pr2 蛋白结构

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (34 - 298)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (34 - 60)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (67 - 92)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (104 - 134)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (145 - 165)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (185 - 214)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (225 - 255)

7tmA_S1PR2_Edg5

7tmA_S1PR2_Edg5: cd15347 (266 - 291)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 2

AGR16

G-protein coupled receptor 13

G-protein coupled receptor H218

S1P receptor 2

S1P receptor Edg-5

S1P2

endothelial differentiation G-protein coupled receptor 5

endothelial differentiation, sphingolipid G-protein-coupled receptor, 5

sphingosine 1-phosphate receptor Edg-5

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12355 Siponimod Agonist 99.95% 否
HY-12355A Siponimod hemifumarate Agonist / 否
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139310 GLPG2938 Antagonist 99.93% 否
HY-111253 CYM-5478 Agonist 99.90% 否
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens S1pr2 NCBI NCBI:9294
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z