S1pr2 - sphingosine-1-phosphate receptor 2 Gene

中文名称：1-磷酸鞘氨醇受体 2

种属: Rattus norvegicus

同用名: Edg5; H218; GPCR18; Gpcr13; snGPCR18

关于 S1pr2

功能概要

该基因编码的蛋白可启动 G 蛋白偶联肽受体活性。作用于 G 蛋白偶联受体信号通路的上游或内部；平滑肌细胞迁移的负调节；血管相关平滑肌细胞增殖的负调节。预计是膜的组成部分。预计在细胞质和质膜中有活性。该基因的人类直向同源基因与常染色体隐性非综合征性耳聋 68 相关。与人类 S1PR2（1-磷酸鞘氨醇受体 2）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled peptide receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway; negative regulation of smooth muscle cell migration; and negative regulation of vascular associated smooth muscle cell proliferation. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 68. Orthologous to human S1PR2 (sphingosine-1-phosphate receptor 2). [provided by Alliance of Genome Resources, Apr 2022]