GSTM4 - glutathione S-transferase mu 4 Gene

中文名称：谷胱甘肽 S-转移酶 mu 4

种属: Homo sapiens

同用名: GTM4; GSTM4-4

关于 GSTM4

功能概要

胞质和膜结合形式的谷胱甘肽 S-转移酶由两个不同的超基因家族编码。目前，已鉴定出八种不同类别的可溶性细胞质哺乳动物谷胱甘肽 S-转移酶：α、κ、μ、ω、pi、sigma、theta 和 zeta。该基因编码属于 mu 类的谷胱甘肽 S-转移酶。 mu 类酶通过与谷胱甘肽结合，在亲电子化合物 (包括致癌物、治疗药物、环境毒素和氧化应激产物) 的解毒中发挥作用。编码 mu 类酶的基因组织在染色体 1p13.3 上的基因簇中，并且已知具有高度多态性。这些遗传变异可以改变个体对致癌物和毒素的易感性，并影响某些药物的毒性和功效。这些基因的多样化发生在编码底物结合域的区域以及组织表达模式中，以适应越来越多的外来化合物。已经鉴定出多个转录本变体，每个变体编码不同的蛋白质亚型。[RefSeq 提供，2008 年 7 月]

Cytosolic and membrane-bound forms of Glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a Glutathione S-transferase that belongs to the mu class. The mu class of Enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of Enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. Multiple transcript variants, each encoding a distinct protein isoform, have been identified. [provided by RefSeq, Jul 2008]