2. Gene
  3. GSTM3 - glutathione S-transferase mu 3 Gene

GSTM3 - glutathione S-transferase mu 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：谷胱甘肽 S-转移酶 mu 3

种属: Homo sapiens

同用名: GST5; GSTB; GTM3; GSTM3-3; hGSTM3-3

基因 ID: 2947 | 基因类型: protein coding

关于 GSTM3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,733,937-109,741,038 (from NCBI)

This gene has 5 transcripts (splice variants), 258 orthologues, 11 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 82.2), kidney (RPKM 34.8) and 16 other tissues.

功能概要

胞质和膜结合形式的谷胱甘肽 S-转移酶由两个不同的超基因家族编码。目前，已鉴定出八种不同类别的可溶性细胞质哺乳动物谷胱甘肽 S-转移酶：α、κ、μ、ω、pi、sigma、theta 和 zeta。该基因编码属于 mu 类的谷胱甘肽 S-转移酶。 mu 类酶通过与谷胱甘肽结合，在亲电子化合物 (包括致癌物、治疗药物、环境毒素和氧化应激产物) 的解毒中发挥作用。编码 mu 类酶的基因组织在染色体 1p13.3 上的基因簇中，并且已知具有高度多态性。这些遗传变异可以改变个体对致癌物和毒素的易感性，并影响某些药物的毒性和功效。此类 mu 基因的突变与许多癌症的轻微增加有关，这可能是由于接触环境毒素所致。可变剪接导致多个转录本变体。[RefSeq 提供，2008 年 11 月]

Cytosolic and membrane-bound forms of Glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a Glutathione S-transferase that belongs to the mu class. The mu class of Enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of Enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Mutations of this class mu gene have been linked with a slight increase in a number of cancers, likely due to exposure with environmental toxins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

GSTM3 基因产物(1)

mRNA Protein Name
NM_000849.5 NP_000840.2 glutathione S-transferase Mu 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
8373352 GOA
enables glutathione binding IDA
IDA: 通过直接分析推断
8373352 GOA
enables glutathione transferase activity IDA
IDA: 通过直接分析推断
8373352 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23355646 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
9545290 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
8373352 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular detoxification of nitrogen compound IDA
IDA: 通过直接分析推断
8373352 GOA
involved in glutathione metabolic process IDA
IDA: 通过直接分析推断
8373352 GOA
involved in nitrobenzene metabolic process IDA
IDA: 通过直接分析推断
8373352 GOA
involved in response to estrogen IEP
IEP: 通过表达模式推断
10037815 GOA
involved in xenobiotic catabolic process IDA
IDA: 通过直接分析推断
8373352 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
8373352 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GSTM3 蛋白结构

GST_N

GST_N: Glutathione S-transferase, N-terminal domain (7 - 86)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (109 - 195)

  • 0
  • 100
  • 200
  • 225 a.a.
蛋白主名 其他名称

glutathione S-transferase Mu 3

GST class-mu 3

GSTM3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GSTM3 P21266 CLVS2 Homo sapiens Q5SYC1
Validated Y2H
32296183
种属内
GSTM3 P21266 CLVS2 Homo sapiens Q5SYC1
Y2H Prey Pooling
32296183
种属内
GSTM3 P21266 CLVS2 Homo sapiens Q5SYC1
Y2H Array
32296183
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Y2H Array
19060904
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Y2H Pooling
16189514
种属内
GSTM3 P21266 GSTM5 Homo sapiens P46439
Y2H Prey Pooling
32296183
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Validated Y2H
32296183
种属内
GSTM3 P21266 GSTM4 Homo sapiens Q03013
Y2H Prey Pooling
32296183
种属内
GSTM3 P21266 GSTM5 Homo sapiens P46439
Validated Y2H
32296183
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Y2H Array
32296183
种属内
GSTM3 P21266 GSTM5 Homo sapiens P46439
Y2H Array
32296183
种属内
GSTM3 P21266 GSTM5 Homo sapiens P46439
MAPPIT
32296183
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Y2H Prey Pooling
32296183
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Y2H
21516116
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Y2H Array
31515488
种属内
GSTM3 P21266 GSTM5 Homo sapiens P46439
Complementation
32296183
种属内
GSTM3 P21266 GSTM3 Homo sapiens P21266
Y2H Pooling
19060904
种属内
GSTM3 P21266 GSTM5 Homo sapiens P46439
Y2H Array
31515488
种属内
GSTM3 P21266 GSTM4 Homo sapiens Q03013
Validated Y2H
32296183
种属内
GSTM3 P21266 GSTM4 Homo sapiens Q03013
Y2H Array
32296183
种属内
GSTM3 P21266 GSTM4 Homo sapiens Q03013
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Larynx Cancer

Laryngeal Carcinoma

Laryngeal Cancer

Laryngeal Neoplasm

Carcinoma Of Larynx

Malignant Neoplasm Of Larynx

Cancer Of Larynx

Laryngeal Neoplasms

Cancer, Laryngeal
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Pharynx Cancer

Pharyngeal Cancer

Pharyngeal Neoplasms

Pharyngeal Neoplasm

Pharynx Neoplasm

Malignant Neoplasm Of Pharynx

Pharyngeal Carcinoma
Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Larynx

Squamous Cell Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Head And Neck
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Open-Angle Glaucoma

Glaucoma Simplex

Pigmentary Glaucoma

Wide-Angle Glaucoma

Glaucoma, Open-Angle

Open Angle Glaucoma

Glaucoma Open-Angle

Chronic Simple Glaucoma

Coag - [Chronic Open-Angle Glaucoma]

Csg - [Chronic Simple Glaucoma]

Poag - [Primary Open-Angle Glaucoma]

Oag - [Open-Angle Glaucoma]

Chronic Glaucoma

Chronic Open Angle Glaucoma

Simple Glaucoma

Chronic Noncongestive Glaucoma

Ltg - [Low Tension Glaucoma]

Noncongestive Glaucoma

Nonobstructive Glaucoma

Normal Pressure Glaucoma

Primary Low Tension Glaucoma

Low-Tension Glaucoma

Residual Stage Low Tension Glaucoma

Open Cleft Glaucoma
Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome

Sudden Unexplained Nocturnal Death Syndrome

Bangungut

Brugada Type Idiopathic Ventricular Fibrillation

Pokkuri Death Syndrome

Sunds

Idiopathic Ventricular Fibrillation, Brugada Type

Sudden Unexplained Death

Dream Disease

Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome

Sudden Unexplained Death Syndrome

Suds

Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Lip And Oral Cavity Cancer

Oral Cancer

Lip And Oral Cavity Carcinoma

Malignant Neoplasm Of Mouth
Cataract

Cataracts

Cat - [Cataract]

Cataract Form

Lens Opacity

Lens Opacities
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-146577 Keap1-Nrf2-IN-7 Inhibitor / 否
HY-146578 Keap1-Nrf2-IN-8 Inhibitor / 否
HY-149245 Keap1-Nrf2-IN-15 Inhibitor / 否
HY-RS05881 GSTM3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-162096 Keap1-Nrf2-IN-17 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GSTM3 MGD MGI:1309466
Rattus norvegicus GSTM3 RGD RGD:61964
Canis familiaris GSTM3 VGNC VGNC:54033
Felis catus GSTM3 VGNC VGNC:108363
Bos taurus GSTM3 VGNC VGNC:29686
Macaca mulatta GSTM3 VGNC VGNC:73303
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