2. Gene
  3. Rgs4 - regulator of G-protein signaling 4 Gene

Rgs4 - regulator of G-protein signaling 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白信号调节器 4

种属: Rattus norvegicus

基因 ID: 29480 | 基因类型: protein coding

关于 Rgs4

Primary_assembly 13: 81,936,775-81,943,068 reverse strand.mRatBN7.2:CM026986.1

This gene has 3 transcripts (splice variants), 197 orthologues, 22 paralogues and is associated with 13 phenotypes. Biased expression in Brain (RPKM 76.9), Adrenal (RPKM 271.2) and 4 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白 α 亚基结合活性和 GTP 酶激活剂活性。参与多个过程，包括调节离子传输；调节信号转导；和对生物碱的反应。位于胞质溶胶中；核;和质膜。部分含蛋白质复合物。用于研究癫痫。膀胱疾病的生物标志物；高血压;坐骨神经损伤;阿片类药物滥用；和癫痫持续状态。与人 RGS4（G 蛋白信号转导 4 的调节因子）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in several processes, including regulation of ion transport; regulation of signal transduction; and response to alkaloid. Located in cytosol; nucleus; and plasma membrane. Part of protein-containing complex. Used to study epilepsy. Biomarker of bladder disease; hypertension; lesion of sciatic nerve; opioid abuse; and status epilepticus. Orthologous to human RGS4 (regulator of G protein signaling 4). [provided by Alliance of Genome Resources, Apr 2022]

Rgs4 基因产物(1)

mRNA Protein Name
NM_017214.2 NP_058910.1 regulator of G-protein signaling 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-protein alpha-subunit binding IDA
IDA: 通过直接分析推断
9108480 RGD
enables G-protein alpha-subunit binding IPI
IPI: 通过物理相互作用推断
20530129 RGD
enables GTPase activator activity IDA
IDA: 通过直接分析推断
10942773 RGD
enables GTPase activator activity IMP
IMP: 通过突变表型推断
9430692 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
17084383 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dorsal root ganglion development IEP
IEP: 通过表达模式推断
14550772 RGD
involved in negative regulation of G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9918533 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IDA
IDA: 通过直接分析推断
9918533 RGD
involved in negative regulation of dopamine receptor signaling pathway IDA
IDA: 通过直接分析推断
21896332 RGD
involved in negative regulation of glycine import across plasma membrane IMP
IMP: 通过突变表型推断
21798518 RGD
involved in negative regulation of potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
24421355 RGD
involved in positive regulation of GTPase activity IMP
IMP: 通过突变表型推断
9430692 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
17220354 RGD
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
25844489 RGD
involved in regulation of actin filament organization IDA
IDA: 通过直接分析推断
9918533 RGD
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
16699510 RGD
involved in regulation of potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
11906535 RGD
involved in response to amphetamine IEP
IEP: 通过表达模式推断
26321241 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
17632279 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
28736108 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
9108480 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rgs4 蛋白结构

RGS_RGS4

RGS_RGS4: cd08714 (62 - 175)

  • 0
  • 100
  • 205 a.a.
蛋白主名 其他名称

regulator of G-protein signaling 4

RGP4

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13509 CCG-50014 Inhibitor 99.42% 否
HY-U00431 CCG 203769 Inhibitor 99.76% 否
HY-70074 CCG-63802 Inhibitor 98.83% 否
HY-110054 CCG-2046 Inhibitor / 否
HY-122251 CCG-4986 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rgs4 NCBI NCBI:5999
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