2. Gene
  3. Slc1a2 - solute carrier family 1 member 2 Gene

Slc1a2 - solute carrier family 1 member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 1 成员 2

种属: Rattus norvegicus

同用名: Glt; Eaat2; Glt-1

基因 ID: 29482 | 基因类型: protein coding

关于 Slc1a2

Primary_assembly 3: 89,005,129-89,126,498 forward strand.mRatBN7.2:CM026976.1

This gene has 7 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 9 phenotypes. Restricted expression toward (RPKM 1451.5).

功能概要

该基因编码的蛋白可启动高亲和力谷氨酸跨膜转运蛋白活性。参与 L-谷氨酸跨膜转运。位于几种细胞成分中，包括星形胶质细胞投射；树突;和突触前膜。是质膜的组成部分。膜蛋白复合物的一部分。该基因的人类直向同源基因与发育和癫痫性脑病 41 相关。与人类 SLC1A2（溶质载体家族 1 成员 2）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables high-affinity glutamate transmembrane transporter activity. Involved in L-glutamate transmembrane transport. Located in several cellular components, including astrocyte projection; dendrite; and presynaptic membrane. Is integral component of plasma membrane. Part of membrane protein complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 41. Orthologous to human SLC1A2 (solute carrier family 1 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a2 基因产物(3)

mRNA Protein Name
NM_001035233.2 NP_001030310.2 excitatory amino acid transporter 2 isoform b
NM_001302089.2 NP_001289018.1 excitatory amino acid transporter 2 isoform c
NM_017215.3 NP_058911.2 excitatory amino acid transporter 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutamate:sodium symporter activity IDA
IDA: 通过直接分析推断
1448170 RGD
enables high-affinity L-glutamate transmembrane transporter activity IDA
IDA: 通过直接分析推断
1448170 RGD
enables high-affinity L-glutamate transmembrane transporter activity IMP
IMP: 通过突变表型推断
10899959 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-glutamate transmembrane transport IMP
IMP: 通过突变表型推断
10899959 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte projection IDA
IDA: 通过直接分析推断
9334410 RGD
located in cell body IDA
IDA: 通过直接分析推断
9334410 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
11896154 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
11950769 RGD
part of membrane protein complex IDA
IDA: 通过直接分析推断
9334410 RGD
located in plasma membrane IMP
IMP: 通过突变表型推断
1448170 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
11896154 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Slc1a2 蛋白结构

SDF

SDF: pfam00375 (45 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 573 a.a.
蛋白主名 其他名称

excitatory amino acid transporter 2

glial glutamate transporter GLT1/V3

glial glutamate transporter GLT1/V4

glutamate transporter 1

high affinity glucose transporter

sodium-dependent glutamatespartate transporter 2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13051 SLC1A2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13052 Slc1a2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS13053 Slc1a2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Slc1a2 NCBI NCBI:6506
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