2. Gene
  3. P2ry2 - purinergic receptor P2Y2 Gene

P2ry2 - purinergic receptor P2Y2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 Y2

种属: Rattus norvegicus

同用名: P2Y2

基因 ID: 29597 | 基因类型: protein coding

关于 P2ry2

Primary_assembly 1: 155,351,165-155,367,632 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 201 orthologues, 13 paralogues and is associated with 12 phenotypes. Biased expression in Liver (RPKM 266.1), Muscle (RPKM 112.6) and 7 other tissues.

功能概要

该基因编码的蛋白可启动 A1 腺苷受体结合活性； ATP结合活性；和 G 蛋白偶联的 UTP 受体活性。参与多个过程，包括阴茎勃起的正调节；细胞溶质钙离子浓度的调节；和细胞分泌的调节。位于顶端质膜和基底外侧质膜。在谷氨酸能突触中活跃。是突触前活动区膜的组成部分。与早期内体共定位；溶酶体；和线粒体。用于研究阳痿。与人 P2RY2（嘌呤能受体 P2Y2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables A1 Adenosine Receptor binding activity; ATP binding activity; and G protein-coupled UTP receptor activity. Involved in several processes, including positive regulation of penile erection; regulation of cytosolic calcium ion concentration; and regulation of secretion by cell. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with early endosome; lysosome; and mitochondrion. Used to study impotence. Orthologous to human P2RY2 (purinergic receptor P2Y2). [provided by Alliance of Genome Resources, Apr 2022]

P2ry2 基因产物(1)

mRNA Protein Name
NM_017255.2 NP_058951.2 P2Y purinoceptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables A1 adenosine receptor binding IPI
IPI: 通过物理相互作用推断
11390975 RGD
enables ATP binding IDA
IDA: 通过直接分析推断
11557527 RGD
enables G protein-coupled UTP receptor activity IDA
IDA: 通过直接分析推断
15924261 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11390975 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in blood vessel diameter maintenance IDA
IDA: 通过直接分析推断
12730558 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
19317852 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
18689605 RGD
involved in cellular response to purine-containing compound IEP
IEP: 通过表达模式推断
16831297 RGD
involved in in utero embryonic development IEP
IEP: 通过表达模式推断
14517997 RGD
NOT involved in microglial cell activation IMP
IMP: 通过突变表型推断
11245682 RGD
involved in negative regulation of ossification IDA
IDA: 通过直接分析推断
12210747 RGD
involved in positive regulation of chemokine production IDA
IDA: 通过直接分析推断
17947675 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
19155635 RGD
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
15379893 RGD
involved in positive regulation of penile erection IDA
IDA: 通过直接分析推断
19303093 RGD
involved in positive regulation of prostaglandin secretion IDA
IDA: 通过直接分析推断
15840771 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
11934835 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IEP
IEP: 通过表达模式推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IEP
IEP: 通过表达模式推断
16000618 RGD
involved in response to growth factor IEP
IEP: 通过表达模式推断
14714568 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
located in early endosome IDA
IDA: 通过直接分析推断
15924261 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16000618 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16000618 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
16000618 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2ry2 蛋白结构

7tmA_P2Y2

7tmA_P2Y2: cd15373 (33 - 315)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (33 - 60)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (67 - 92)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (105 - 135)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (147 - 169)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (194 - 223)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (236 - 266)

7tmA_P2Y2

7tmA_P2Y2: cd15373 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

P2Y purinoceptor 2

ATP receptor

P2U purinoceptor 1

P2U1

P2Y ATP receptor 2

purinergic receptor P2Y, G-protein coupled, 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09928 P2RY2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09929 P2ry2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09930 P2ry2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2ry2 NCBI NCBI:5029
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