Alox5ap - arachidonate 5-lipoxygenase activating protein Gene

中文名称：花生四烯酸 5-脂氧合酶激活蛋白

种属: Rattus norvegicus

关于 Alox5ap

功能概要

该基因编码的蛋白可启动酶结合活性和相同的蛋白质结合活性。有助于花生四烯酸 5-脂氧合酶活性。参与白三烯生物合成过程；脂氧合酶途径；和急性炎症反应的正调节作用。位于胞质溶胶中；内质网；和核膜。用于研究肺动脉高压。肾小球肾炎的生物标志物。该基因的人类直系同源物与多种疾病有关，包括哮喘；脑梗塞（多发）；乳腺癌;脑瘫；和冠状动脉疾病（多种）。与人类 ALOX5AP（花生四烯酸 5-脂氧合酶激活蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Enzyme binding activity and identical protein binding activity. Contributes to arachidonate 5-lipoxygenase activity. Involved in leukotriene biosynthetic process; Lipoxygenase pathway; and positive regulation of acute inflammatory response. Located in cytosol; endoplasmic reticulum; and nuclear envelope. Used to study pulmonary hypertension. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). [provided by Alliance of Genome Resources, Apr 2022]