2. Gene
  3. Kcnj2 - potassium inwardly-rectifying channel, subfamily J, member 2 Gene

Kcnj2 - potassium inwardly-rectifying channel, subfamily J, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Kir2.1

基因 ID: 29712 | 基因类型: protein coding

关于 Kcnj2

功能概要

Predicted to enable identical protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and voltage-gated Potassium Channel activity. Involved in cellular response to mechanical stimulus; positive regulation of potassium ion transmembrane transport; and regulation of cardiac muscle cell contraction. Located in several cellular components, including T-tubule; endoplasmic reticulum; and intercalated disc. Used to study myocardial infarction. Human ortholog(s) of this gene implicated in Andersen-Tawil syndrome; familial atrial fibrillation; familial periodic paralysis; and short QT syndrome. Orthologous to human KCNJ2 (potassium inwardly rectifying channel subfamily J member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnj2 基因产物(1)

mRNA Protein Name
NM_017296.2 NP_058992.1 inward rectifier potassium channel 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22509027 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
17293496 RGD
involved in positive regulation of potassium ion transmembrane transport IMP
IMP: 通过突变表型推断
22426100 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: 通过突变表型推断
22426100 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
23640888 RGD
located in dendrite IDA
IDA: 通过直接分析推断
12591157 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
18076085 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18076085 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
23640888 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12591157 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
18076085 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

inward rectifier potassium channel 2

IRK-1

RBL-IRK1

inward rectifier K(+) channel Kir2.1

potassium channel, inwardly rectifying subfamily J member 2

potassium voltage-gated channel subfamily J member 2

Kcnj2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Kcnj2 Q64273 Dlg1 Rattus norvegicus Q62696
Anti Bait CoIP
22509027
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07145 KCNJ2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kcnj2 NCBI NCBI:3759
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