2. Gene
  3. Dlg1 - discs large MAGUK scaffold protein 1 Gene

Dlg1 - discs large MAGUK scaffold protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Dlgh1; SAP97

基因 ID: 25252 | 基因类型: protein coding

关于 Dlg1

功能概要

Enables several functions, including PDZ domain binding activity; ionotropic glutamate receptor binding activity; and Kinesin binding activity. Involved in several processes, including cell adhesion; neurotransmitter receptor localization to postsynaptic specialization membrane; and positive regulation of potassium ion transport. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and paranode region of axon. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Dlg1 基因产物(2)

mRNA Protein Name
NM_001393734.1 NP_001380663.1 disks large homolog 1 isoform 2
NM_012788.2 NP_036920.2 disks large homolog 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
15024025 RGD
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
14597197 RGD
enables kinesin binding IPI
IPI: 通过物理相互作用推断
12097473 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
1127911 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12933808 RGD
enables transmembrane transporter binding IPI
IPI: 通过物理相互作用推断
11181181 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell adhesion IEP
IEP: 通过表达模式推断
7891172 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IDA
IDA: 通过直接分析推断
14597197 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
14597197 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
12805297 RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: 通过突变表型推断
12805297 RGD
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
14597197 RGD
involved in positive regulation of potassium ion transport IMP
IMP: 通过突变表型推断
19213956 RGD
involved in regulation of protein localization IMP
IMP: 通过突变表型推断
17635915 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
11181181 RGD
located in basal plasma membrane IDA
IDA: 通过直接分析推断
7891172 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11726633 RGD
located in cytosol IDA
IDA: 通过直接分析推断
19587293 RGD
located in dendrite IDA
IDA: 通过直接分析推断
17301176 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11029631 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
12805297 RGD
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
8638125 RGD
located in microvillus IDA
IDA: 通过直接分析推断
19587293 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
8638125 RGD
located in paranode region of axon IDA
IDA: 通过直接分析推断
19587293 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
17301176 RGD
is active in postsynaptic density, intracellular component IDA
IDA: 通过直接分析推断
11029631 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
7891172 RGD
located in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
8638125 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

disks large homolog 1

Drosophila discs-large tumor suppressor homologue (synapse associated protein)

discs large homolog 1, scribble cell polarity complex component

discs, large homolog 1

synapse-associated protein 97

Dlg1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Dlg1 Q62696 DLGAP1 Homo sapiens O14490
FPS
22117215
Cross Dlg1 Q62696 BTRC Homo sapiens Q9Y297
Pull Down
12902344
Intra Dlg1 Q62696 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
21119615
Intra Dlg1 Q62696 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
16332687
Intra Dlg1 Q62696 Map1a Rattus norvegicus P34926
Far-WB
9786987
Cross Dlg1 Q62696 PTEN Homo sapiens P60484
Pull Down
15951562
Intra Dlg1 Q62696 Kcnj2 Rattus norvegicus Q64273
Anti Bait CoIP
22509027
Cross Dlg1 Q62696 E4 Human adenovirus D P89079
Anti Tag CoIP
16511562
Cross Dlg1 Q62696 E4 Human adenovirus D P89079
Anti Bait CoIP
9192623
Cross Dlg1 Q62696 Gpsm2 Mus musculus Q8VDU0
FPS
22117215
Cross Dlg1 Q62696 Gpsm2 Mus musculus Q8VDU0
X-Ray Diffraction
22117215
Intra Dlg1 Q62696 Dgki Rattus norvegicus F1MAB7
Anti Bait CoIP
21119615
Intra Dlg1 Q62696 Dgki Rattus norvegicus F1MAB7
Pull Down
21119615
Intra Dlg1 Q62696 Lrfn2 Rattus norvegicus Q460M5
Anti Bait CoIP
16495444
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03796 DLG1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dlg1 NCBI NCBI:1739
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