2. Gene
  3. DLGAP1 - DLG associated protein 1 Gene

DLGAP1 - DLG associated protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：DLG 相关蛋白 1

种属: Homo sapiens

同用名: DAP1; GKAP; DAP-1; SAPAP1; DLGAP1A; DLGAP1B; DAP-1-BETA; DAP-1-ALPHA

基因 ID: 9229 | 基因类型: protein coding

关于 DLGAP1

Cytogenetic location: 18p11.31 Genomic coordinates (GRCh38): 18:3,496,032-4,455,307 (from NCBI)

This gene has 22 transcripts (splice variants), 286 orthologues and 4 paralogues. Biased expression in brain (RPKM 19.8), testis (RPKM 1.7) and 2 other tissues.

功能概要

预测启用分子适配器活动。预计是突触后密度的结构成分。预计将参与多个过程，包括侵略性组装；突触后神经递质受体活性的调节；和调节蛋白酶体蛋白质分解代谢过程。预测位于质膜中。预测为突触后密度的一部分。预计在谷氨酸能突触和突触后密度、细胞内成分中具有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable molecular adaptor activity. Predicted to be a structural constituent of postsynaptic density. Predicted to be involved in several processes, including aggresome assembly; regulation of postsynaptic neurotransmitter receptor activity; and regulation of proteasomal protein catabolic process. Predicted to be located in plasma membrane. Predicted to be part of postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2022]

DLGAP1 基因产物(29)

mRNA Protein Name
NM_001003809.3 NP_001003809.1 disks large-associated protein 1 isoform 2
NM_001242761.2 NP_001229690.1 disks large-associated protein 1 isoform 3
NM_001242762.2 NP_001229691.1 disks large-associated protein 1 isoform 4
NM_001242763.2 NP_001229692.1 disks large-associated protein 1 isoform 5
NM_001242764.2 NP_001229693.1 disks large-associated protein 1 isoform 6
NM_001242765.2 NP_001229694.1 disks large-associated protein 1 isoform 7
NM_001242766.2 NP_001229695.1 disks large-associated protein 1 isoform 8
NM_001308390.2 NP_001295319.1 disks large-associated protein 1 isoform 9
NM_001398525.1 NP_001385454.1 disks large-associated protein 1 isoform 10
NM_001398526.1 NP_001385455.1 disks large-associated protein 1 isoform 10
NM_001398527.1 NP_001385456.1 disks large-associated protein 1 isoform 1
NM_001398528.1 NP_001385457.1 disks large-associated protein 1 isoform 11
NM_001398530.1 NP_001385459.1 disks large-associated protein 1 isoform 12
NM_001398531.1 NP_001385460.1 disks large-associated protein 1 isoform 13
NM_001398532.1 NP_001385461.1 disks large-associated protein 1 isoform 14
NM_001398533.1 NP_001385462.1 disks large-associated protein 1 isoform 15
NM_001398534.1 NP_001385463.1 disks large-associated protein 1 isoform 16
NM_001398535.1 NP_001385464.1 disks large-associated protein 1 isoform 17
NM_001398536.1 NP_001385465.1 disks large-associated protein 1 isoform 18
NM_001398537.1 NP_001385466.1 disks large-associated protein 1 isoform 19
NM_001398539.1 NP_001385468.1 disks large-associated protein 1 isoform 20
NM_001398540.1 NP_001385469.1 disks large-associated protein 1 isoform 21
NM_001398541.1 NP_001385470.1 disks large-associated protein 1 isoform 22
NM_001398542.1 NP_001385471.1 disks large-associated protein 1 isoform 23
NM_001398543.1 NP_001385472.1 disks large-associated protein 1 isoform 24
NM_001398544.1 NP_001385473.1 disks large-associated protein 1 isoform 25
NM_001398545.1 NP_001385474.1 disks large-associated protein 1 isoform 26
NM_001398546.1 NP_001385475.1 disks large-associated protein 1 isoform 27
NM_004746.4 NP_004737.2 disks large-associated protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DLGAP1 蛋白结构

GKAP

GKAP: Guanylate-kinase-associated protein (GKAP) protein (640 - 977)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 977 a.a.
蛋白主名 其他名称

disks large-associated protein 1

PSD-95/SAP90 binding protein 1

DLGAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DLGAP1 O14490 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra DLGAP1 O14490 DLG4 Homo sapiens P78352
Y2H Pooling
21653829
Intra DLGAP1 O14490 DLG4 Homo sapiens P78352
FPS
22117215
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 55

RP55

Retinitis Pigmentosa, Type 55
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior
Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder
Transient Tic Disorder
Childhood Acute Megakaryoblastic Leukemia

Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Phelan-Mcdermid Syndrome

Chromosome 22q13.3 Deletion Syndrome

22q13.3 Deletion Syndrome

Telomeric 22q13 Monosomy Syndrome

PHMDS

Deletion 22q13 Syndrome

22q13.3 Deletion

Deletion 22q13.3 Syndrome

Monosomy 22q13

Monosomy 22q13.3

22q13 Deletion Syndrome

Monosomy 22q13 Syndrome

22q13 Deletion

Chromosome Deletion
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Body Dysmorphic Disorder

Dysmorphophobia

Body Dysmorphia

Dysmorphic Syndrome

Body Dysmorphic Disorders
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Gilles De La Tourette Syndrome

Tourette Syndrome

Tourette Disorder

GTS

Ts

Gilles De La Tourette'S Syndrome

Motor-Verbal Tic Disorder

Guinon'S Disease

Psychogenic Tics

Tourette'S Syndrome

Chronic Motor And Vocal Tic Disorder

Td

Tourette'S Disease

Combined Vocal And Multiple Motor Tic Disorder [De La Tourette]

Combined Vocal And Multiple Motor Tic Disorder

Tic De La Tourette
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03801 DLGAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DLGAP1 MGD MGI:1346065
Canis familiaris DLGAP1 VGNC VGNC:39979
Rattus norvegicus DLGAP1 RGD RGD:620223
Bos taurus DLGAP1 VGNC VGNC:28088
Felis catus DLGAP1 VGNC VGNC:80437
Macaca mulatta DLGAP1 VGNC VGNC:97759
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