1. Gene
  2. GUCY1A2 - guanylate cyclase 1 soluble subunit alpha 2 Gene

GUCY1A2 - guanylate cyclase 1 soluble subunit alpha 2 Gene

中文名称:鸟苷酸环化酶 1 可溶性亚基 alpha 2

种属: Homo sapiens

同用名: GC-SA2; GUC1A2

基因 ID: 2977 | 基因类型: protein coding

关于 GUCY1A2

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:106,674,019-107,018,476 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 17 paralogues. Broad expression in endometrium (RPKM 8.8), placenta (RPKM 7.4) and 15 other tissues.

功能概要

可溶性鸟苷酸环化酶是异源二聚体蛋白,可催化 GTP 转化为 3',5'-环 GMP 和焦磷酸盐。由该基因编码的蛋白质是该复合物的一个 α 亚基,它与一个 β 亚基相互作用形成鸟苷酸环化酶,该酶被一氧化氮激活。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供,2012 年 1 月]

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the Guanylate Cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GUCY1A2 基因产物(2)

mRNA Protein Name
NM_000855.3 NP_000846.1 guanylate cyclase soluble subunit alpha-2 isoform 2
NM_001256424.2 NP_001243353.1 guanylate cyclase soluble subunit alpha-2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24550280 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GUCY1A2 蛋白结构

HNOB

HNOB: Haem-NO-binding (150 - 274)

HNOBA

HNOBA: Heme NO binding associated (314 - 506)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (513 - 683)

  • 0
  • 200
  • 400
  • 600
  • 732 a.a.
蛋白主名 其他名称

guanylate cyclase soluble subunit alpha-2

GCS-alpha-2

GUCY1A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GUCY1A2 P33402 GSC2 Homo sapiens O15499
Y2H Array
32296183
种属内
GUCY1A2 P33402 GSC2 Homo sapiens O15499
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus GUCY1A2 MGD MGI:2660877
Bos taurus GUCY1A2 VGNC VGNC:29719
Macaca mulatta GUCY1A2 VGNC VGNC:82154
Canis familiaris GUCY1A2 VGNC VGNC:41566
Felis catus GUCY1A2 VGNC VGNC:103035
Rattus norvegicus GUCY1A2 RGD RGD:621655