2. Gene
  3. GUCA2B - guanylate cyclase activator 2B Gene

GUCA2B - guanylate cyclase activator 2B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鸟苷酸环化酶激活因子 2B

种属: Homo sapiens

同用名: UGN; GCAP-II

基因 ID: 2981 | 基因类型: protein coding

关于 GUCA2B

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:42,153,410-42,155,820 (from NCBI)

This gene has 1 transcript (splice variant), 148 orthologues and 1 paralogue. Biased expression in small intestine (RPKM 47.4), colon (RPKM 37.0) and 1 other tissue.

功能概要

该基因编码一种前原蛋白，该蛋白经过蛋白水解处理可产生多种蛋白质产物，包括尿鸟苷蛋白、鸟苷蛋白肽家族的成员和鸟苷酸环化酶-C 受体的内源性配体。这种肽与其同源受体的结合会刺激循环 GMP 的增加，并可能调节肠道和肾脏中的盐和水稳态。[RefSeq 提供，2015 年 11 月]

This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products, including uroguanylin, a member of the guanylin family of Peptides and an endogenous ligand of the guanylate cyclase-C receptor. Binding of this peptide to its cognate receptor stimulates an increase in cyclic GMP and may regulate salt and water homeostasis in the intestine and kidneys. [provided by RefSeq, Nov 2015]

GUCA2B 基因产物(1)

mRNA Protein Name
NM_007102.3 NP_009033.1 guanylate cyclase activator 2B preproprotein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GUCA2B 蛋白结构

Guanylin

Guanylin: Guanylin precursor (25 - 111)

  • 0
  • 100
  • 112 a.a.
蛋白主名 其他名称

guanylate cyclase activator 2B

prepro-uroguanylin

GUCA2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GUCA2B Q16661 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
GUCA2B Q16661 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
GUCA2B Q16661 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属内
GUCA2B Q16661 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Cataract 8, Multiple Types

Ccv

Cataract, Congenital, Volkmann Type

CTRCT8

Cataract 8 Multiple Types

Cataract Congenital Volkmann Type

Cutaneous Collagenous Vasculopathy
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Secretory Diarrhea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05917 GUCA2B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GUCA2B MGD MGI:1270851
Bos taurus GUCA2B VGNC VGNC:29717
Rattus norvegicus GUCA2B RGD RGD:620044
Felis catus GUCA2B VGNC VGNC:67513
Canis familiaris GUCA2B VGNC VGNC:41565
Macaca mulatta GUCA2B VGNC VGNC:73326
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