2. Gene
  3. SNX8 - sorting nexin 8 Gene

SNX8 - sorting nexin 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：排序 nexin 8

种属: Homo sapiens

同用名: Mvp1

基因 ID: 29886 | 基因类型: protein coding

关于 SNX8

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:2,251,770-2,354,497 (from NCBI)

This gene has 9 transcripts (splice variants), 220 orthologues and 15 paralogues. Broad expression in spleen (RPKM 12.6), testis (RPKM 7.0) and 24 other tissues.

功能概要

实现相同的蛋白质结合活性和磷脂酰肌醇结合活性。参与早期内体到高尔基体的转运和细胞内蛋白质转运。位于早期内体膜。与逆转录酶复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and phosphatidylinositol binding activity. Involved in early endosome to Golgi transport and intracellular protein transport. Located in early endosome membrane. Colocalizes with retromer complex. [provided by Alliance of Genome Resources, Apr 2022]

SNX8 基因产物(1)

mRNA Protein Name
NM_013321.4 NP_037453.1 sorting nexin-8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
23085988 GOA
enables phosphatidylinositol binding IMP
IMP: 通过突变表型推断
19782049 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in early endosome to Golgi transport IMP
IMP: 通过突变表型推断
19782049 GOA
involved in intracellular protein transport IMP
IMP: 通过突变表型推断
19782049 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome membrane IDA
IDA: 通过直接分析推断
19782049 GOA
part of retromer complex IDA
IDA: 通过直接分析推断
19782049 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNX8 蛋白结构

PX

PX: PX domain (84 - 178)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 465 a.a.
蛋白主名 其他名称

sorting nexin-8

SNX8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SNX8 Q9Y5X2 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
种属内
SNX8 Q9Y5X2 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
种属内
SNX8 Q9Y5X2 POR Homo sapiens P16435
Anti Tag CoIP
28514442
种属内
SNX8 Q9Y5X2 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
种属内
SNX8 Q9Y5X2 FBXW7 Homo sapiens Q969H0
Anti Tag CoIP
33961781
种属内
SNX8 Q9Y5X2 FBXW7 Homo sapiens Q969H0
Anti Tag CoIP
28514442
种属内
SNX8 Q9Y5X2 RABAC1 Homo sapiens Q9UI14
Y2H Array
32296183
种属内
SNX8 Q9Y5X2 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
种属内
SNX8 Q9Y5X2 LACC1 Homo sapiens Q8IV20
Anti Tag CoIP
33961781
种属内
SNX8 Q9Y5X2 LACC1 Homo sapiens Q8IV20
Anti Tag CoIP
28514442
种属内
SNX8 Q9Y5X2 POR Homo sapiens P16435
Anti Tag CoIP
33961781
种属内
SNX8 Q9Y5X2 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
种属内
SNX8 Q9Y5X2 NCK1 Homo sapiens P16333
Peptide Array
17474147
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Atrial Tachyarrhythmia With Short Pr Interval

Lown-Ganong-Levine Syndrome

Syndrome Of Short P-R Interval, Normal Qrs Complexes, And Supraventricular Tachycardias

Lgl Syndrome
Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13547 SNX8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SNX8 VGNC VGNC:65559
Canis familiaris SNX8 VGNC VGNC:46644
Bos taurus SNX8 VGNC VGNC:35114
Macaca mulatta SNX8 VGNC VGNC:77703
Rattus norvegicus SNX8 RGD RGD:1305791
Mus musculus SNX8 MGD MGI:2443816
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