1. Gene
  2. SNX11 - sorting nexin 11 Gene

SNX11 - sorting nexin 11 Gene

中文名称:排序 nexin 11

种属: Homo sapiens

基因 ID: 29916 | 基因类型: protein coding

关于 SNX11

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,107,523-48,123,601 (from NCBI)

This gene has 13 transcripts (splice variants), 206 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 9.8), spleen (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码分选连接蛋白家族的一个成员。该家族的成员包含一个 phox (PX) 结构域,它是一个磷酸肌醇结合结构域,并参与细胞内运输。这种蛋白质不像某些家族成员那样包含卷曲螺旋区域。该基因编码一种功能未知的蛋白质。该基因导致两个转录变体在 5' UTR 上不同,但编码相同的蛋白质。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene encodes a protein of unknown function. This gene results in two transcript variants differing in the 5' UTR, but encoding the same protein. [provided by RefSeq, Jul 2008]

SNX11 基因产物(3)

mRNA Protein Name
NM_001330320.2 NP_001317249.1 sorting nexin-11 isoform 2
NM_013323.3 NP_037455.2 sorting nexin-11 isoform 1
NM_152244.2 NP_689450.1 sorting nexin-11 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol phosphate binding IDA
IDA: 通过直接分析推断
23615901 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in vesicle organization IMP
IMP: 通过突变表型推断
23615901 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
26818531 GOA
located in endosome IDA
IDA: 通过直接分析推断
23615901 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
26818531 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SNX11 蛋白结构

PX

PX: PX domain (15 - 128)

  • 0
  • 100
  • 200
  • 270 a.a.
蛋白主名 其他名称

sorting nexin-11

SNX11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SNX11 Q9Y5W9 RPRM Homo sapiens Q9NS64
Y2H Array
32296183
种属内
SNX11 Q9Y5W9 RPRM Homo sapiens Q9NS64
Y2H Prey Pooling
32296183
种属内
SNX11 Q9Y5W9 SMYD2 Homo sapiens Q9NRG4
Y2H Array
32296183
种属内
SNX11 Q9Y5W9 SMYD2 Homo sapiens Q9NRG4
Y2H Prey Pooling
32296183
种属内
SNX11 Q9Y5W9 REEP6 Homo sapiens Q96HR9-2
Y2H Prey Pooling
32296183
种属内
SNX11 Q9Y5W9 REEP6 Homo sapiens Q96HR9-2
Y2H Array
32296183
种属内
SNX11 Q9Y5W9 MAJIN Homo sapiens Q3KP22-3
Y2H Array
32296183
种属内
SNX11 Q9Y5W9 MAJIN Homo sapiens Q3KP22-3
Y2H Prey Pooling
32296183
种属内
SNX11 Q9Y5W9 YIF1A Homo sapiens O95070
Y2H Array
32296183
种属内
SNX11 Q9Y5W9 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
种属内
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Y2H Array
25416956
种属内
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
25416956
种属内
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Validated Y2H
25416956
种属内
SNX11 Q9Y5W9 RABAC1 Homo sapiens Q9UI14
Y2H Prey Pooling
32296183
种属内
SNX11 Q9Y5W9 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
25416956
种属内
SNX11 Q9Y5W9 ARL6IP1 Homo sapiens Q15041
Y2H Prey Pooling
32296183
种属内
SNX11 Q9Y5W9 ARL6IP1 Homo sapiens Q15041
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Penis Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Penis

Epidermoid Cell Carcinoma Of Penis

Squamous Cell Carcinoma Of The Penis

Penile Squamous Cell Carcinoma

Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency

Pnpo Deficiency

Pyridoxamine 5'-Phosphate Oxidase Deficiency

Pnpo-Related Neonatal Epileptic Encephalopathy

Pyridoxal Phosphate-Responsive Seizures

Pyridoxal 5'-Phosphate-Dependent Epilepsy

Pyridoxine-5'-Phosphate Oxidase Deficiency

PNPOD

Seizures, Pyridoxine-Resistant, Plp-Sensitive

Pyridoxal Phosphate-Dependent Seizures

Pyridoxamine 5'-Oxidase Deficiency

Epileptic Encephalopathy, Neonatal, Pnpo-Related

Pyridox Ine 5'-Phosphate Oxidase Deficiency

Deficiency, Pyridoxamine 5'-Phosphate Oxidase

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus SNX11 VGNC VGNC:35092
Rattus norvegicus SNX11 RGD RGD:1307319
Mus musculus SNX11 MGD MGI:1921729
Macaca mulatta SNX11 VGNC VGNC:77706
Felis catus SNX11 VGNC VGNC:65542
Canis familiaris SNX11 VGNC VGNC:46621