DONSON - DNA replication fork stabilization factor DONSON Gene

中文名称：DNA 复制叉稳定因子 DONSON

种属: Homo sapiens

同用名: B17; MIMIS; MISSLA; C21orf60

基因 ID: 29980 | 基因类型: protein coding

关于 DONSON

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,577,551-33,588,684 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and is associated with 4 phenotypes. Broad expression in testis (RPKM 22.3), urinary bladder (RPKM 14.4) and 23 other tissues.

功能概要

该基因位于 SON 基因的下游，在 21 号染色体上跨越 10 kb。该基因的功能未知。[RefSeq 提供，2008 年 7 月]

This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

DONSON 基因产物(1)

mRNA	Protein	Name
NM_017613.4	NP_060083.1	protein downstream neighbor of Son

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	28191891	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	28191891	GOA
involved in DNA replication	IMP IMP: 通过突变表型推断	28191891	GOA
involved in mitotic DNA replication checkpoint signaling	IMP IMP: 通过突变表型推断	28191891	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: 通过突变表型推断	28191891	GOA
involved in replication fork processing	IMP IMP: 通过突变表型推断	28191891	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	28191891	GOA
located in replication fork	IDA IDA: 通过直接分析推断	28191891	GOA
part of replisome	IDA IDA: 通过直接分析推断	28191891	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

protein downstream neighbor of Son

downstream neighbor of SON

DONSON 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DONSON	Q9NYP3	MCM2	Homo sapiens	P49736	Anti Bait CoIP	32769987
种属内	DONSON	Q9NYP3	MCM2	Homo sapiens	P49736	Anti Tag CoIP	32769987
种属内	DONSON	Q9NYP3	GINS1	Homo sapiens	Q14691	Anti Bait CoIP	32769987
种属内	DONSON	Q9NYP3	GINS1	Homo sapiens	Q14691	Anti Tag CoIP	32769987

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Microcephaly, Short Stature, And Limb Abnormalities

MISSLA	Microcephaly-Short Stature-Limb Abnormalities Syndrome
Microcephaly, Short Stature, Limb Abnormalities

Microcephaly-Micromelia Syndrome

MIMIS

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

Meier-Gorlin Syndrome 5

MGORS5

Meier-Gorlin Syndrome, Type 5

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Seckel Syndrome

Microcephalic Primordial Dwarfism	Bird-Headed Dwarfism
Harper'S Syndrome	Virchow-Seckel Dwarfism
Nanocephalic Dwarfism	Sckl
Seckel-Type Dwarfism

Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies

Image Syndrome	IMAGE
Intrauterine Growth Retardation-Metaphyseal Dysplasia-Adrenal Hypoplasia Congenita-Genital Anomalies Syndrome	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Abnormalities	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Anomalies
Image Anomaly	Image Association
Fetal Growth Retardation	Pyle Metaphyseal Dysplasia

Isolated Growth Hormone Deficiency, Type Ia

Ighd Ia	Primordial Dwarfism
Isolated Growth Hormone Deficiency Type Ia	Sexual Ateleiotic Dwarfism
Pituitary Dwarfism I	IGHD1A
Illig-Type Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, Type Ia
Congenital Ighd Type Ia	Congenital Isolated Gh Deficiency Type Ia
Congenital Isolated Growth Hormone Deficiency Type Ia	Pituitary Dwarfism 1
Growth Hormone Deficiency, Isolated, Autosomal Recessive	Autosomal Recessive Isolated Growth Hormone Deficiency
Isolated Growth Hormone Deficiency Type 1a	Congenital Ighd
Congenital Isolated Gh Deficiency	Congenital Isolated Growth Hormone Deficiency
Growth Hormone Deficiency, Isolated Autosomal Recessive	Illig Type Growth Hormone Deficiency
Non-Acquired Isolated Growth Hormone Deficiency	Growth Hormone Deficiency, Isolated, 1a
Growth Hormone Deficiency Isolated Autosomal Recessive	Dwarfism, Primordial
Dwarfism

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03941	DONSON Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	DONSON	VGNC	VGNC:96918
Macaca mulatta	DONSON	VGNC	VGNC:103810
Bos taurus	DONSON	VGNC	VGNC:56216
Rattus norvegicus	DONSON	RGD	RGD:1306823
Mus musculus	DONSON	MGD	MGI:1890621

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

DONSON - DNA replication fork stabilization factor DONSON Gene

关于 DONSON

功能概要

DONSON 基因产物(1)

DONSON 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

DONSON - DNA replication fork stabilization factor DONSON Gene

关于 DONSON

功能概要

DONSON 基因产物(1)

DONSON 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z