GINS1 - GINS complex subunit 1 Gene

中文名称：轧棉厂复杂亚基 1

种属: Homo sapiens

同用名: PSF1; IMD55

基因 ID: 9837 | 基因类型: protein coding

关于 GINS1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,407,673-25,448,563 (from NCBI)

This gene has 25 transcripts (splice variants), 201 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 4.5), lymph node (RPKM 2.0) and 19 other tissues.

功能概要

酵母异四聚体 GINS 复合体由 Sld5 (GINS4；MIM 610611) 、Psf1、Psf2 (GINS2；MIM 610609) 和 Psf3 (GINS3；MIM 610610) 组成。 GINS 复合物的形成对于酵母和爪蟾卵提取物中 DNA 复制的启动至关重要 (Ueno 等人，2005 [PubMed 16287864]) 。[OMIM 提供，2008 年 3 月]

The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]

GINS1 基因产物(3)

mRNA	Protein	Name
NM_001410830.1	NP_001397759.1	DNA replication complex GINS protein PSF1 isoform 2
NM_001410831.1	NP_001397760.1	DNA replication complex GINS protein PSF1 isoform 3
NM_021067.5	NP_066545.3	DNA replication complex GINS protein PSF1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	17417653	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA unwinding involved in DNA replication	IDA IDA: 通过直接分析推断	22474384	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CMG complex	IPI IPI: 通过物理相互作用推断	22474384	GOA
part of GINS complex	IPI IPI: 通过物理相互作用推断	17417653	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10942595	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10942595	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

DNA replication complex GINS protein PSF1

GINS complex subunit 1 (Psf1 homolog)

GINS1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	GINS1	Q14691	DONSON	Homo sapiens	Q9NYP3	PLA	32769987
种属内	GINS1	Q14691	DONSON	Homo sapiens	Q9NYP3	Anti Bait CoIP	32769987
种属内	GINS1	Q14691	GINS4	Homo sapiens	Q9BRT9	GMS	17652513
种属内	GINS1	Q14691	GINS4	Homo sapiens	Q9BRT9	Solution Sedimentation	17417653
种属内	GINS1	Q14691	GINS4	Homo sapiens	Q9BRT9	X-Ray Diffraction	17417653
种属内	GINS1	Q14691	GINS4	Homo sapiens	Q9BRT9	Ion Exchange Chrom	17652513
种属内	GINS1	Q14691	GINS4	Homo sapiens	Q9BRT9	X-Ray Diffraction	17652513
种属内	GINS1	Q14691	GINS4	Homo sapiens	Q9BRT9	Anti Tag CoIP	33961781
种属内	GINS1	Q14691	GINS4	Homo sapiens	Q9BRT9	GMS	17417653

种属间: 跨种属相互作用 种属内: 同种属相互作用

GINS1 抗体

目录号	产品名	应用	反应物种
HY-P82018	PSF1 Antibody (YA1763)	WB, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Immunodeficiency 55

Combined Immunodeficiency Due To Gins1 Deficiency	IMD55
Cid Due To Gins1 Deficiency	Combined Immunodeficiency With Intrauterine Growth Retardation-Nk Cell Deficiency-Neutropenia
Combined Immunodeficiency With Intrauterine Growth Retardation-Natural Killer Cell Deficiency-Neutropenia

Neutropenia

Leukopenia

Nk Cell Deficiency

Dendritic Cell Deficiency

Adrenal Cortical Adenocarcinoma

Adrenal Cortex Adenocarcinoma

Adrenocortical Carcinoma

Immunodeficiency 54

Natural Killer Cell Deficiency, Familial Isolated	Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency
IMD54	Nkcd
Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect	Nkgcd
Familial Isolated Natural Killer Cell Deficiency	Primary Immunodeficiency Due To Mcm4 Deficiency

Hemophagocytic Lymphohistiocytosis, Familial, 2

Familial Hemophagocytic Lymphohistiocytosis 2	FHL2
Hplh2	Hlh2
Hemophagocytic Lymphohistiocytosis, Familial, 2, Susceptibility To	Lymphohistiocytosis, Hemophagocytic, Familial, Type 2

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Immunodeficiency 21

Monocytopenia And Mycobacterial Infection Syndrome	Monomac
Gata2 Deficiency	Monocytopenia With Susceptibility To Infections
Dcml	IMD21
Dendritic Cell, Monocyte, B Lymphocyte, And Natural Killer Lymphocyte Deficiency	Monocytopenia With Susceptibility To Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia
Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral, And Fungal Infections	Combined Immunodeficiency With Susceptibility To Mycobacterial, Viral And Fungal Infections
Dendritic Cell, Monocyte, B And Nk Lymphoid Deficiency	Monocyte-B-Natural Killer-Dendritic Cell Deficiency Syndrome
Monocytopenia With Mycobacterial, Fungal, And Papillomavirus Infections And Myelodysplasia	Combined Immunodeficiency With Mycobacterial, Viral, And Fungal Infections
Monocyte - B - Natural Killer - Dendritic Cell Deficiency	Combined Immunodeficiency With Susceptibility To Mycobacterial Viral And Fungal Infections
Dendritic Cell Monocyte Lymphocyte B And Natural Killer Lymphocyte Deficiency	Monocytopenia With Susceptibility To Mycobacterial Fungal And Papillomavirus Infections And Myelodysplasia

Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies

Image Syndrome	IMAGE
Intrauterine Growth Retardation-Metaphyseal Dysplasia-Adrenal Hypoplasia Congenita-Genital Anomalies Syndrome	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, And Genital Anomalies
Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Abnormalities	Intrauterine Growth Restriction, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, Genital Anomalies
Image Anomaly	Image Association
Fetal Growth Retardation	Pyle Metaphyseal Dysplasia

Meier-Gorlin Syndrome 1

Meier-Gorlin Syndrome	Ear, Patella, Short Stature Syndrome
Microtia, Absent Patellae, Micrognathia Syndrome	MGORS1
Eps	Ear-Patella-Short Stature Syndrome
Ear Patella Short Stature Syndrome	Microtia Absent Patellae Micrognathia Syndrome
Meier-Gorlin Syndrome, Type 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W279260	APOBEC3G-IN-1	Inhibitor	96.54%	否
HY-RS05429	GIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS05430	GINS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	GINS1	VGNC	VGNC:29360
Mus musculus	GINS1	MGD	MGI:1916520
Rattus norvegicus	GINS1	RGD	RGD:1562246
Macaca mulatta	GINS1	VGNC	VGNC:73025

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

GINS1 - GINS complex subunit 1 Gene

关于 GINS1

功能概要

GINS1 基因产物(3)

GINS1 蛋白互作信息

GINS1 抗体

关联疾病

直系同源

热门区域

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GINS1 - GINS complex subunit 1 Gene

关于 GINS1

功能概要

GINS1 基因产物(3)

GINS1 蛋白互作信息

GINS1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z