TBX21 - T-box transcription factor 21 Gene

中文名称：T 盒转录因子 21

种属: Homo sapiens

同用名: TBET; IMD88; T-PET; T-bet; TBLYM

基因 ID: 30009 | 基因类型: protein coding

关于 TBX21

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,733,236-47,746,122 (from NCBI)

This gene has 2 transcripts (splice variants), 305 orthologues, 16 paralogues and is associated with 2 phenotypes. Biased expression in spleen (RPKM 4.5), bone marrow (RPKM 4.1) and 12 other tissues.

功能概要

该基因是系统发育保守基因家族的成员，该家族共享一个共同的 DNA 结合域，即 T 盒。 T-box 基因编码参与发育过程调控的转录因子。该基因是小鼠 Tbx21/Tbet 基因的人类直向同源基因。小鼠研究表明，Tbx21 蛋白是一种 Th1 细胞特异性转录因子，可控制标志性 Th1 细胞因子干扰素-γ (IFNG) 的表达。人类直系同源物的表达也与 Th1 和自然杀伤细胞中的 IFNG 表达相关，表明该基因在启动幼稚 Th 前体细胞的 Th1 谱系发育中的作用。[RefSeq 提供，2008 年 7 月]

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

TBX21 基因产物(1)

mRNA	Protein	Name
NM_013351.2	NP_037483.1	T-box transcription factor TBX21

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	18504404	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15662016	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23332764	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	19805038	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in lymphocyte migration	IDA IDA: 通过直接分析推断	19805038	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18504404	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	19805038	GOA
involved in response to virus	IEP IEP: 通过表达模式推断	20583921	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TBX21 蛋白结构

T-box

0
100
200
300
400
500
535 a.a.

蛋白主名

其他名称

T-box transcription factor TBX21

T-box 21

TBX21 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TBX21	Q9UL17	SP1	Homo sapiens	P08047	Anti Bait CoIP	17075044
种属内	TBX21	Q9UL17	SP1	Homo sapiens	P08047	Anti Tag CoIP	17075044
种属内	TBX21	Q9UL17	EP300	Homo sapiens	Q09472	Anti Bait CoIP	17075044
种属内	TBX21	Q9UL17	EP300	Homo sapiens	Q09472	Anti Tag CoIP	17075044
种属内	TBX21	Q9UL17	GATA3	Homo sapiens	P23771	Anti Bait CoIP	17075044
种属内	TBX21	Q9UL17	GATA3	Homo sapiens	P23771	Anti Tag CoIP	17075044
种属内	TBX21	Q9UL17	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	17075044
种属内	TBX21	Q9UL17	CREBBP	Homo sapiens	Q92793	Anti Tag CoIP	17075044

种属间: 跨种属相互作用 种属内: 同种属相互作用

TBX21 抗体

目录号	产品名	应用	反应物种
HY-P81472	T-bet / Tbx21 Antibody (YA1217)	IHC-P	Human
HY-P81757	T Box Protein 21 Antibody (YA1502)	IHC-P, FC	Human

关联疾病

疾病名称

别名

Asthma, Nasal Polyps, And Aspirin Intolerance

Asthma And Nasal Polyps	Asa Triad
Asthma, Aspirin-Induced, Susceptibility To	Asthma, Aspirin-Induced
Asthma, With Nasal Polyps And Aspirin Intolerance	ANPAI
Aia	Aspirin-Intolerant Asthma
Asthma Aspirin-Induced	Nasal Polyps Asthma And Aspirin Sensitivity
Samter Triad	Asthma With Aspirin Triad Including Nonsteroidal Anti-Inflammatory Activity And Nasal Polyps

Immunodeficiency 88

IMD88

Immunodeficiency 88, Mycobacteriosis, Autosomal Recessive

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Type 1 Diabetes Mellitus 21

Diabetes Mellitus, Insulin-Dependent, 21	Iddm21
T1D21	Insulin-Dependent Diabetes Mellitus 21

Aneruptive Fever

Rickettsia Helvetica Spotted Fever

Autoimmune Disease Of Eyes, Ear, Nose And Throat

Autoimmune Uveitis

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Autoimmune Myocarditis

Parasitic Helminthiasis Infectious Disease

Helminthiasis	Intestinal Helminthiasis
Helminth Infection	Helminthosis
Worm Infection	Worm Infections
Helminth Infections	Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata
Parasitic Enteritis	Metazoal Dysentery
Intestinal Worms Nos

Respiratory Allergy

Airway Allergy

Listeriosis

Listeria Infection	Infection By Listeria Monocytogenes
Listeria Monocytogenes Infection	Listeria Infections
Listerial Foodborne Infection	Circling Disease
Infection Due To Listeria Monocytogenes	Listerellosis

Chronic Asthma

Salmonellosis

Salmonella Infections

Salmonella Infection

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Autoimmune Disease Of Central Nervous System

Dermatitis, Atopic, 5

ATOD5	Atopic Dermatitis 5
Dermatitis, Atopic, Susceptibility To, 5	Dermatitis, Atopic 5

Autoimmune Disease Of Gastrointestinal Tract

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

Immunodeficiency 27b

Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency	IMD27B
Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant	Ifngr1 Deficiency, Autosomal Dominant
Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency	Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency
Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency	Immunodeficiency 27b, Mycobacteriosis, Ad
Autosomal Dominant Ifngr1 Deficiency	Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis
Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14277	TBX21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TBX21	RGD	RGD:1308264
Mus musculus	TBX21	MGD	MGI:1888984
Bos taurus	TBX21	VGNC	VGNC:35668
Felis catus	TBX21	VGNC	VGNC:66005
Macaca mulatta	TBX21	VGNC	VGNC:78271
Canis familiaris	TBX21	VGNC	VGNC:47173

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TBX21 - T-box transcription factor 21 Gene

关于 TBX21

功能概要

TBX21 基因产物(1)

TBX21 蛋白结构

TBX21 蛋白互作信息

TBX21 抗体

关联疾病

直系同源

热门区域

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TBX21 - T-box transcription factor 21 Gene

关于 TBX21

功能概要

TBX21 基因产物(1)

TBX21 蛋白结构

TBX21 蛋白互作信息

TBX21 抗体

关联疾病

相关产品

直系同源

热门区域

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