2. Gene
  3. H1-4 - H1.4 linker histone, cluster member Gene

H1-4 - H1.4 linker histone, cluster member Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：H1.4 接头组蛋白，簇成员

种属: Homo sapiens

同用名: H1E; H1.4; H1F4; RMNS; H1s-4; HIST1H1E; dJ221C16.5

基因 ID: 3008 | 基因类型: protein coding

关于 H1-4

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,156,329-26,157,115 (from NCBI)

This gene has 1 transcript (splice variant), 128 orthologues, 9 paralogues and is associated with 2 phenotypes.

功能概要

组蛋白是负责真核生物染色体纤维核小体结构的基本核蛋白。四个核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一个的两个分子形成一个八聚体，大约 146 bp 的 DNA 被包裹在称为核小体的重复单元中。接头组蛋白 H1 与核小体之间的接头 DNA 相互作用，并在将染色质压缩成更高级结构中发挥作用。该基因是无内含子的，编码复制依赖组蛋白，该组蛋白是组蛋白 H1 家族的一员。该基因的转录本缺少 polyA 尾巴，而是包含一个回文终止元件。该基因存在于 6 号染色体上的大型组蛋白基因簇中。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-4 基因产物(1)

mRNA Protein Name
NM_005321.3 NP_005312.1 histone H1.4
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin DNA binding IMP
IMP: 通过突变表型推断
15911621 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
15469825 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in heterochromatin IDA
IDA: 通过直接分析推断
15911621 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17540172 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

H1-4 蛋白结构

Linker_histone

Linker_histone: linker histone H1 and H5 family (38 - 109)

  • 0
  • 100
  • 200
  • 219 a.a.
蛋白主名 其他名称

histone H1.4

H1 histone family, member 4

H1-4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra H1-4 P10412 H2BC21 Homo sapiens Q16778
Crosslink
30021884
Intra H1-4 P10412 L3MBTL1 Homo sapiens Q9Y468
Pull Down
17540172
Cross H1-4 P10412 N SARS-CoV-2 P0DTC9
Anti Tag CoIP
36217030
Intra H1-4 P10412 UTP3 Homo sapiens Q9NQZ2
Anti Tag CoIP
33961781
Intra H1-4 P10412 FTSJ3 Homo sapiens Q8IY81
Anti Tag CoIP
33961781
Intra H1-4 P10412 FTSJ3 Homo sapiens Q8IY81
Anti Tag CoIP
28514442
Intra H1-4 P10412 BAZ1B Homo sapiens Q9UIG0
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rahman Syndrome

RMNS
Hist1h1e Syndrome

Rahman Syndrome
Plasma Cell Neoplasm

Plasma Cell Dyscrasia

Paraproteinemias

Plasma Cell Tumour

Plasmacytic Tumor

Multiple Myeloma

Plasmacytoma

Plasma Cell Tumours

Plasma Cells Dyscrasia
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066
Weaver Syndrome

Wss

Weaver-Smith Syndrome

WVS

Weaver-Like Syndrome

Weaver-Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies Syndrome

Camptodactyly - Overgrowth - Unusual Facies

Ezh2 Related Overgrowth

Overgrowth Syndrome With Accelerated Skeletal Maturation, Unusual Facies, And Camptodactyly

Weaver Smith Syndrome

Weaver Like Syndrome

Weaver Williams Syndrome

Camptodactyly-Overgrowth-Unusual Facies

Weaver Syndrome 1

Weaver Syndrome 2

Wvs1

Wvs2
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10587 BIX-01294 98.75% 否
HY-108239 BIX-01294 trihydrochloride / 否
HY-RS05949 H1-4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-N1682 2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus H1-4 VGNC VGNC:109858
Bos taurus H1-4 VGNC VGNC:83559
Macaca mulatta H1-4 VGNC VGNC:109744
Mus musculus H1-4 MGD MGI:1931527
Canis familiaris H1-4 VGNC VGNC:83756
Rattus norvegicus H1-4 RGD RGD:2776
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z