HDGF - heparin binding growth factor Gene

中文名称：肝素结合生长因子

种属: Homo sapiens

同用名: HMG1L2

基因 ID: 3068 | 基因类型: protein coding

关于 HDGF

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,742,107-156,767,366 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 90.4), liver (RPKM 48.1) and 25 other tissues.

功能概要

该基因编码肝细胞瘤衍生生长因子家族的一个成员。编码的蛋白质具有促有丝分裂和 DNA 结合活性，可能在细胞增殖和分化中发挥作用。该基因的高水平表达促进了许多肿瘤的生长。该基因最初被认为位于 X 染色体上；然而，该位置已被确定为对应于相关的假基因。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]

HDGF 基因产物(6)

mRNA	Protein	Name
NM_001126050.2	NP_001119522.1	hepatoma-derived growth factor isoform b
NM_001126051.1	NP_001119523.1	hepatoma-derived growth factor isoform c
NM_001319186.2	NP_001306115.1	hepatoma-derived growth factor isoform d
NM_001319187.2	NP_001306116.1	hepatoma-derived growth factor isoform e
NM_001319188.2	NP_001306117.1	hepatoma-derived growth factor isoform e
NM_004494.3	NP_004485.1	hepatoma-derived growth factor isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin binding	IDA IDA: 通过直接分析推断	26845719	GOA
NOT enables heparin binding	IDA IDA: 通过直接分析推断	26845719	GOA
enables heparin binding	IDA IDA: 通过直接分析推断	26845719	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	26845719	GOA
enables transcription corepressor activity	IDA IDA: 通过直接分析推断	19162039	GOA
enables transcription corepressor binding	IPI IPI: 通过物理相互作用推断	19162039	GOA
enables tubulin binding	IDA IDA: 通过直接分析推断	26845719	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	19162039	GOA
NOT involved in positive regulation of cell division	IDA IDA: 通过直接分析推断	26845719	GOA
involved in positive regulation of cell division	IDA IDA: 通过直接分析推断	26845719	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	26845719	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	27926477	GOA
located in nucleus	IDA IDA: 通过直接分析推断	26845719	GOA
part of transcription repressor complex	IDA IDA: 通过直接分析推断	19162039	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HDGF 蛋白结构

PWWP

0
100
200
240 a.a.

蛋白主名

其他名称

hepatoma-derived growth factor

epididymis secretory sperm binding protein

重组 HDGF 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70368	HDGF Protein, Human (His)	P51858-1 (M1-Y100)	≥95%
HY-P700087AF	Animal-Free HDGF Protein, Human (His)	P51858-1 (M1-L240)	≥95%

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06094	HDGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HDGF	RGD	RGD:70961
Canis familiaris	HDGF	VGNC	VGNC:41627
Mus musculus	HDGF	MGD	MGI:1194494
Felis catus	HDGF	VGNC	VGNC:103733
Macaca mulatta	HDGF	VGNC	VGNC:99967
Bos taurus	HDGF	VGNC	VGNC:29787
Others	HDGF	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HDGF - heparin binding growth factor Gene

关于 HDGF

功能概要

HDGF 基因产物(6)

HDGF 蛋白结构

重组 HDGF 蛋白

关联疾病

直系同源

热门区域

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HDGF - heparin binding growth factor Gene

关于 HDGF

功能概要

HDGF 基因产物(6)

HDGF 蛋白结构

重组 HDGF 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z