1. Gene
  2. ACAT2 - acetyl-CoA acetyltransferase 2 Gene

ACAT2 - acetyl-CoA acetyltransferase 2 Gene

中文名称:乙酰辅酶 A 乙酰转移酶 2

种属: Rattus norvegicus

同用名: Acat3; Ab2-076

基因 ID: 308100 | 基因类型: protein coding

关于 ACAT2

Primary_assembly 1: 47,695,788-47,752,821 forward strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 213 orthologues, 7 paralogues and is associated with 7 phenotypes. Biased expression in Liver (RPKM 12.4), Brain (RPKM 14.9) and 9 other tissues.

功能概要

该基因编码的蛋白可启动乙酰辅酶 A C-乙酰转移酶活性。参与多个过程,包括胆汁酸信号通路;酮体分解代谢过程;和肝脏发育。位于胞质溶胶中。过早绝经的生物标志物。该基因的人类直系同源物与冠状动脉疾病有关。与人类 ACAT2(乙酰辅酶 A 乙酰转移酶 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables acetyl-CoA C-acetyltransferase activity. Involved in several processes, including bile acid signaling pathway; ketone body catabolic process; and liver development. Located in cytosol. Biomarker of premature menopause. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

ACAT2 基因产物(1)

mRNA Protein Name
NM_001006995.1 NP_001006996.1 acetyl-CoA acetyltransferase, cytosolic
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetyl-CoA C-acetyltransferase activity IDA
IDA: 通过直接分析推断
10806397 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to fatty acid IEP
IEP: 通过表达模式推断
11786296 RGD
involved in cellular response to nutrient IEP
IEP: 通过表达模式推断
12563020 RGD
involved in ketone body catabolic process IEP
IEP: 通过表达模式推断
5116556 RGD
involved in liver development IEP
IEP: 通过表达模式推断
5166591 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ACAT2 蛋白结构

PRK05790

PRK05790: PRK05790 (7 - 395)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
蛋白主名 其他名称

acetyl-CoA acetyltransferase, cytosolic

acetyl-Coenzyme A acetyltransferase 2

acetyl-Coenzyme A acetyltransferase 3

cytosolic acetoacetyl-CoA thiolase

重组 ACAT2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75543 ACAT2 Protein, Rat (His) Q5XI22 (M1-G397) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens ACAT2 NCBI NCBI:39