TAX1BP3 - Tax1 binding protein 3 Gene

中文名称：Tax1 结合蛋白 3

种属: Homo sapiens

同用名: TIP1; TIP-1

关于 TAX1BP3

功能概要

该基因编码一种具有单个 PDZ 结构域的小型、高度保守的蛋白质。 PDZ (PSD-95/Discs large/ZO-1 同源) 结构域促进影响细胞信号传导、粘附、蛋白质支架以及受体和离子转运蛋白功能的蛋白质-蛋白质相互作用。编码的蛋白质与大量在信号通路中发挥作用的靶蛋白相互作用；例如，它与 Rho A 和谷氨酰胺酶 L 相互作用，还充当 Wnt/β-连环蛋白信号通路的负调节因子。这种蛋白质首先被鉴定为与 T 细胞白血病病毒 (HTLV1) Tax 癌蛋白结合。该基因的过度表达与癌细胞粘附、迁移和转移的改变有关。编码的蛋白质还调节内向整流钾通道 2.3 (Kir2.3) 的定位和密度。迄今为止，这种蛋白质已被证明在细胞增殖、发育、应激反应和极化中发挥作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 4 月]

This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and Glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered Cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying Potassium Channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2017]