2. Gene
  3. ANXA11 - annexin A11 Gene

ANXA11 - annexin A11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：膜联蛋白 A11

种属: Homo sapiens

同用名: ALS23; ANX11; CAP50; CAP-50; IBMWMA

基因 ID: 311 | 基因类型: protein coding

关于 ANXA11

Cytogenetic location: 10q22.3 Genomic coordinates (GRCh38): 10:80,150,889-80,205,808 (from NCBI)

This gene has 10 transcripts (splice variants), 217 orthologues, 12 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 36.2), heart (RPKM 32.2) and 25 other tissues.

功能概要

该基因编码膜联蛋白家族的一个成员，膜联蛋白家族是一组钙依赖性磷脂结合蛋白。膜联蛋白具有独特的 N 末端结构域和保守的 C 末端结构域，其中包含钙依赖性磷脂结合位点。编码的蛋白质是一种 56-kD 抗原，可被各种自身免疫性疾病患者的血清识别。已经确定了几种编码两种不同亚型的转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

ANXA11 基因产物(6)

mRNA Protein Name
NM_001157.3 NP_001148.1 annexin A11 isoform 1
NM_001278407.2 NP_001265336.1 annexin A11 isoform 1
NM_001278408.2 NP_001265337.1 annexin A11 isoform 1
NM_001278409.2 NP_001265338.1 annexin A11 isoform 2
NM_145868.2 NP_665875.1 annexin A11 isoform 1
NM_145869.2 NP_665876.1 annexin A11 isoform 1

ANXA11 蛋白结构

Annexin

Annexin: Annexin (204 - 269)

Annexin

Annexin: Annexin (277 - 341)

Annexin

Annexin: Annexin (359 - 424)

Annexin

Annexin: Annexin (435 - 499)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

annexin A11

56 kDa autoantigen

ANXA11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ANXA11 P50995 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
种属内
ANXA11 P50995 NFKBID Homo sapiens Q8NI38
Y2H Prey Pooling
32296183
种属内
ANXA11 P50995 NFKBID Homo sapiens Q8NI38
Y2H Array
32296183
种属内
ANXA11 P50995 KRTAP13-2 Homo sapiens Q52LG2
Y2H Prey Pooling
32296183
种属内
ANXA11 P50995 KRTAP13-2 Homo sapiens Q52LG2
Validated Y2H
32296183
种属内
ANXA11 P50995 KRTAP13-2 Homo sapiens Q52LG2
Y2H Array
32296183
种属内
ANXA11 P50995 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
种属内
ANXA11 P50995 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
种属内
ANXA11 P50995 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
种属内
ANXA11 P50995 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
种属内
ANXA11 P50995 WWOX Homo sapiens Q9NZC7-5
Y2H Array
32296183
种属内
ANXA11 P50995 WWOX Homo sapiens Q9NZC7-5
Y2H Prey Pooling
32296183
种属内
ANXA11 P50995 FUBP1 Homo sapiens Q96AE4-2
Y2H Prey Pooling
32296183
种属内
ANXA11 P50995 FUBP1 Homo sapiens Q96AE4-2
Y2H Array
32296183
种属内
ANXA11 P50995 FUBP1 Homo sapiens Q96AE4-2
Validated Y2H
32296183
种属内
ANXA11 P50995 ARSA Homo sapiens P15289
Y2H Prey Pooling
32296183
种属内
ANXA11 P50995 ARSA Homo sapiens P15289
Y2H Array
32296183
种属内
ANXA11 P50995 PDCD6 Homo sapiens O75340
Y2H Array
25910212
种属内
ANXA11 P50995 PDCD6 Homo sapiens O75340
Pull Down
18256029
种属内
ANXA11 P50995 PDCD6 Homo sapiens O75340
Validated Y2H
25910212
种属内
ANXA11 P50995 PDCD6 Homo sapiens O75340
Y2H Bait-Prey Pool
25910212
种属内
ANXA11 P50995 TFG Homo sapiens Q92734
Validated Y2H
25910212
种属内
ANXA11 P50995 TFG Homo sapiens Q92734
Y2H Bait-Prey Pool
25910212
种属内
ANXA11 P50995 TFG Homo sapiens Q92734
Y2H Array
25910212
种属内
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
种属内
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Validated Y2H
25910212
种属内
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Bait-Prey Pool
25910212
种属内
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Validated Y2H
32296183
种属内
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Array
31515488
种属内
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Array
25910212
种属内
ANXA11 P50995 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 23

Amyotrophic Lateral Sclerosis Type 23

ALS23
Inclusion Body Myopathy And Brain White Matter Abnormalities

Multisystem Proteinopathy 6

IBMWMA

Msp6
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Uveoparotid Fever

Heerfordt'S Syndrome
Papillary Hidradenoma

Tubular Sweat Gland Adenomas
Autoimmune Pancreatitis

Lymphoplasmocytic Sclerosing Pancreatitis

Aip
Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1

Frontotemporal Dementia And/Or Motor Neuron Disease

Ftdmnd

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia

Alsftd

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1

Frontotemporal Dementia With Motor Neuron Disease

Ftdals

Ftd-Als

Ftd-Mnd

Frontotemporal Dementia With Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1

Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1

Frontotemporal Lobar Degeneration

Grn-Related Frontotemporal Dementia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00759 ANXA11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ANXA11 VGNC VGNC:37938
Macaca mulatta ANXA11 VGNC VGNC:69946
Rattus norvegicus ANXA11 RGD RGD:1309911
Mus musculus ANXA11 MGD MGI:108481
Felis catus ANXA11 VGNC VGNC:67689
Bos taurus ANXA11 VGNC VGNC:25964
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