2. Gene
  3. HLA-E - major histocompatibility complex, class I, E Gene

HLA-E - major histocompatibility complex, class I, E Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：主要组织相容性复合体，I 类，E 类

种属: Homo sapiens

同用名: QA1; HLA-6.2

基因 ID: 3133 | 基因类型: protein coding

关于 HLA-E

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,489,509-30,494,194 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 572 orthologues and 22 paralogues. Ubiquitous expression in spleen (RPKM 452.2), lung (RPKM 398.4) and 24 other tissues.

功能概要

HLA-E 属于 HLA I 类重链旁系同源物。这种 I 类分子是由重链和轻链 (β2 微球蛋白) 组成的异二聚体。重链锚定在膜中。 HLA-E 结合来自其他 I 类分子前导肽的有限肽子集。重链约为 45 kDa，其基因包含 8 个外显子。外显子 1 编码前导肽，外显子 2 和 3 编码 alpha1 和 alpha2 结构域，它们都结合肽，外显子 4 编码 alpha3 结构域，外显子 5 编码跨膜区域，外显子 6 和 7 编码细胞质尾部。[RefSeq 提供，2008 年 7 月]

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of Peptides derived from the leader Peptides of Other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-E 基因产物(1)

mRNA Protein Name
NM_005516.6 NP_005507.3 HLA class I histocompatibility antigen, alpha chain E precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MHC class I protein binding IDA
IDA: 通过直接分析推断
9754572 GOA
enables T cell receptor binding IDA
IDA: 通过直接分析推断
16474394 GOA
enables beta-2-microglobulin binding IDA
IDA: 通过直接分析推断
16474394 GOA
enables beta-2-microglobulin binding IMP
IMP: 通过突变表型推断
12411439 GOA
enables natural killer cell lectin-like receptor binding IPI
IPI: 通过物理相互作用推断
25631937 GOA
enables peptide antigen binding IDA
IDA: 通过直接分析推断
9427624 GOA
enables peptide antigen binding IMP
IMP: 通过突变表型推断
12411439 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9427624 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
18448674 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CD8-positive, alpha-beta T cell activation IDA
IDA: 通过直接分析推断
25631937 GOA
involved in adaptive immune response IDA
IDA: 通过直接分析推断
25631937 GOA
involved in antibacterial humoral response IDA
IDA: 通过直接分析推断
25631937 GOA
involved in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IDA
IDA: 通过直接分析推断
9754572 GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class Ib IDA
IDA: 通过直接分析推断
20195504 GOA
involved in defense response to Gram-positive bacterium IDA
IDA: 通过直接分析推断
25631937 GOA
involved in natural killer cell tolerance induction IDA
IDA: 通过直接分析推断
9486650 GOA
involved in negative regulation of T cell proliferation IDA
IDA: 通过直接分析推断
20195504 GOA
involved in negative regulation of natural killer cell activation IDA
IDA: 通过直接分析推断
37264229 GOA
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
9486650 GOA
involved in positive regulation of CD8-positive, alpha-beta T cell activation IDA
IDA: 通过直接分析推断
28676677 GOA
involved in positive regulation of CD8-positive, alpha-beta T cell proliferation IDA
IDA: 通过直接分析推断
25631937 GOA
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
20195504 GOA
involved in positive regulation of TRAIL production IDA
IDA: 通过直接分析推断
25631937 GOA
involved in positive regulation of antibody-dependent cellular cytotoxicity IDA
IDA: 通过直接分析推断
30134159 GOA
involved in positive regulation of immunoglobulin production IDA
IDA: 通过直接分析推断
25631937 GOA
involved in positive regulation of interleukin-13 production IDA
IDA: 通过直接分析推断
25631937 GOA
involved in positive regulation of interleukin-4 production IDA
IDA: 通过直接分析推断
25631937 GOA
involved in positive regulation of natural killer cell activation IDA
IDA: 通过直接分析推断
37264229 GOA
involved in positive regulation of natural killer cell cytokine production IDA
IDA: 通过直接分析推断
30134159 GOA
involved in positive regulation of natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
23335510 GOA
involved in positive regulation of natural killer cell mediated immunity IDA
IDA: 通过直接分析推断
9754572 GOA
involved in positive regulation of natural killer cell proliferation IDA
IDA: 通过直接分析推断
30134159 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
25631937 GOA
involved in protection from natural killer cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
9754572 GOA
involved in regulation of natural killer cell mediated immunity IDA
IDA: 通过直接分析推断
18448674 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MHC class I protein complex IDA
IDA: 通过直接分析推断
12411439 GOA
part of MHC class Ib protein complex IDA
IDA: 通过直接分析推断
9427624 GOA
located in cell surface IDA
IDA: 通过直接分析推断
9754572 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9427624 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HLA-E 蛋白结构

MHC_I

MHC_I: Class I Histocompatibility antigen, domains alpha 1 and 2 (22 - 200)

C1-set

C1-set: Immunoglobulin C1-set domain (216 - 292)

  • 0
  • 100
  • 200
  • 300
  • 358 a.a.
蛋白主名 其他名称

HLA class I histocompatibility antigen, alpha chain E

MHC class I antigen E

HLA-E 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HLA-E P13747 HLA-F Homo sapiens P30511
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HLA-E 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77758 HLA-E*0103 Complex Protein, Human (HEK293, His-Avi) P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL ≥95%
HY-P77759 HLA-E*0103 Complex Protein, Human (Biotinylated, HEK293, His-Avi) P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL ≥95%
HY-P77760 HLA-E*0103 Complex Tetramer Protein, Human (HEK293, His-Avi) P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL ≥95%
HY-P77761 HLA-E*0103 Complex Tetramer Protein, Human (Biotinylated, HEK293, His-Avi) P13747 (G22-T302)&P61769 (I21-M119)&VMAPRTLVL ≥95%

关联疾病

疾病名称 别名
Choriocarcinoma

Chorioepithelioma
Rabies

Lyssa

Hydrophobia

St Hubert Disease
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy
Nk Cell Deficiency
Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland
Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency

Mhc Class I Deficiency

Bls, Type I

Bare Lymphocyte Syndrome Type I

Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency

Blsi

Mhc Class 1 Deficiency

Major Histocompatibility Complex Class 1 Deficiency

Bare Lymphocyte Syndrome 1

BLS1

Bls I

Bls Type I

Bl-1

Bare Lymphocyte Syndrome Type 1

Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1

Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens

Bls - [Bare Lymphocyte Syndrome] Nos
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06215 HLA-E Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HLA-E RGD RGD:1595923
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