2. Gene
  3. Pikfyve - phosphoinositide kinase, FYVE-type zinc finger containing Gene

Pikfyve - phosphoinositide kinase, FYVE-type zinc finger containing Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸肌醇激酶，含 FYVE 型锌指

种属: Rattus norvegicus

同用名: Pip5k3

基因 ID: 316457 | 基因类型: protein coding

关于 Pikfyve

Primary_assembly 9: 66,563,727-66,657,868 forward strand.mRatBN7.2:CM026982.1

This gene has 4 transcripts (splice variants), 205 orthologues, 17 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 173.2), Spleen (RPKM 145.9) and 9 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动磷酸转移酶活性、醇基作为受体和锌离子结合活性。预计参与多个过程，包括抗原加工和通过 MHC II 类呈递外源肽抗原；磷脂酰肌醇代谢过程；和囊泡组织。预计在髓鞘组装的上游或内部起作用。预测位于几种细胞成分中，包括细胞质囊泡膜；膜筏；和细胞质的核周区。该基因的人类直系同源物与 Fleck 角膜营养不良有关。与人 PIKfyve 同源（磷酸肌醇激酶，含有 FYVE 型锌指）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable phosphotransferase activity, alcohol group as acceptor and zinc ion binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; phosphatidylinositol metabolic process; and vesicle organization. Predicted to act upstream of or within myelin assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; membrane raft; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKfyve (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]

Pikfyve 基因产物(11)

mRNA Protein Name
XM_006245073.2 XP_006245135.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X3
XM_006245077.4 XP_006245139.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_039084597.1 XP_038940525.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X8
XM_006245076.4 XP_006245138.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_039084596.1 XP_038940524.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X5
XM_006245071.2 XP_006245133.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1
XM_006245074.4 XP_006245136.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4
XM_006245079.2 XP_006245141.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X7
XM_006245078.2 XP_006245140.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X6
XM_006245072.2 XP_006245134.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X2
XM_039084595.1 XP_038940523.1 1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

Pikfyve 蛋白结构

FYVE_PIKfyve_Fab1

FYVE_PIKfyve_Fab1: cd15725 (185 - 246)

DEP_PIKfyve

DEP_PIKfyve: cd04448 (388 - 469)

Fab1_TCP

Fab1_TCP: cd03334 (648 - 908)

PIPKc_PIKfyve

PIPKc_PIKfyve: cd17300 (1848 - 2114)

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  • 2129 a.a.
蛋白主名 其他名称

1-phosphatidylinositol-3-phosphate 5-kinase

1-phosphatidylinositol 3-phosphate 5-kinase

phosphatidylinositol-3-phosphate 5-kinase type III

phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III

phosphoinositide kinase, FYVE finger containing

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-14644 Apilimod Inhibitor 99.80% Phase 2
HY-14644A Apilimod mesylate Inhibitor 99.83% Phase 2
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13228 YM-201636 Inhibitor 98.05% 否
HY-118630 Vacuolin-1 Inhibitor 98.93% 否
HY-15982 APY0201 Inhibitor 99.93% 否
HY-119624 MOMIPP Inhibitor 99.37% 否
HY-155994 PIK5-12d Degrader 99.90% 否
HY-151473 PIKfyve-IN-1 Inhibitor 99.64% 否
HY-160477 DC-SX029 Inhibitor 98.07% 否
HY-163133 PIKfyve-IN-3 99.55% 否
HY-161619 RMC-113 Inhibitor 98.17% 否
HY-154956 PIKfyve-IN-2 Inhibitor / 否
HY-163943 UNI418 Inhibitor / 否
HY-159625 WX8 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pikfyve NCBI NCBI:200576
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