HNRNPL - heterogeneous nuclear ribonucleoprotein L Gene

中文名称：异质核核糖核蛋白 L

种属: Homo sapiens

同用名: HNRPL; hnRNP-L; P/OKcl.14

关于 HNRNPL

功能概要

包括 mRNA 前体和成熟 mRNA 的异质核 RNA (hnRNA) 与特定蛋白质相关，形成异质核糖核蛋白 (hnRNP) 复合物。异质核核糖核蛋白 L 是与 hnRNP 复合物稳定相关的蛋白质之一，并且与其他 hnRNP 蛋白质一起可能在 mRNA 的形成、包装、加工和功能中发挥重要作用。异质核核糖核蛋白 L 作为 HNRP 复合物的一部分存在于核质中。 HNRP 蛋白也已在核质外被鉴定出来。 hnRNP 与 mRNA 结合蛋白的交换伴随着 mRNA 从细胞核向细胞质的转运。由于已证明 HNRP 蛋白在细胞核和细胞质之间穿梭，因此它们可能也具有细胞质功能。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]