2. Gene
  3. Gpr4 - G protein-coupled receptor 4 Gene

Gpr4 - G protein-coupled receptor 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 4

种属: Mus musculus

基因 ID: 319197 | 基因类型: protein coding

关于 Gpr4

Chromosome 7: 18,946,463-18,958,099 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 141 orthologues, 16 paralogues and is associated with 30 phenotypes. Ubiquitous expression in lung adult (RPKM 11.4), subcutaneous fat pad adult (RPKM 11.1) and 25 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联受体活性。参与炎症反应的正向调节和血管通透性的调节。作用于多个过程的上游或内部，包括血管发育；血管生成的负调节；和对酸性 pH 值的反应。预测位于质膜中。预计是质膜的组成部分。与人类 GPR4（G 蛋白偶联受体 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity. Involved in positive regulation of inflammatory response and regulation of vascular permeability. Acts upstream of or within several processes, including blood vessel development; negative regulation of angiogenesis; and response to acidic pH. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Gpr4 基因产物(1)

mRNA Protein Name
NM_175668.4 NP_783599.1 G-protein coupled receptor 4
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
17145776 MGI
enables G protein-coupled receptor activity IMP
IMP: 通过突变表型推断
17145776 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
17145776 MGI
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
17145776 MGI
acts upstream of or within angiogenesis involved in wound healing IDA
IDA: 通过直接分析推断
17145776 MGI
acts upstream of or within glomerular mesangial cell development IMP
IMP: 通过突变表型推断
17145776 MGI
acts upstream of or within negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
17145776 MGI
involved in positive regulation of inflammatory response IMP
IMP: 通过突变表型推断
32058960 MGI
involved in regulation of vascular permeability IMP
IMP: 通过突变表型推断
32058960 MGI
acts upstream of or within response to acidic pH IDA
IDA: 通过直接分析推断
17145776 MGI
acts upstream of or within response to acidic pH IMP
IMP: 通过突变表型推断
17145776 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Gpr4 蛋白结构

7tmA_GPR4

7tmA_GPR4: cd15366 (19 - 46)

7tmA_GPR4

7tmA_GPR4: cd15366 (19 - 298)

7tmA_GPR4

7tmA_GPR4: cd15366 (53 - 78)

7tmA_GPR4

7tmA_GPR4: cd15366 (91 - 121)

7tmA_GPR4

7tmA_GPR4: cd15366 (133 - 155)

7tmA_GPR4

7tmA_GPR4: cd15366 (179 - 208)

7tmA_GPR4

7tmA_GPR4: cd15366 (218 - 248)

7tmA_GPR4

7tmA_GPR4: cd15366 (266 - 291)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
蛋白主名 其他名称

G-protein coupled receptor 4

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101784 NE 52-QQ57 99.89% 否
HY-101536 GPR4 antagonist 1 Antagonist 98.92% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpr4 NCBI NCBI:2828
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