HOXD3 - homeobox D3 Gene

中文名称：同源框 D3

种属: Homo sapiens

同用名: HOX4; HOX1D; HOX4A; Hox-4.1

关于 HOXD3

功能概要

该基因属于同源盒基因家族。同源框基因编码一个高度保守的转录因子家族，在所有多细胞生物的形态发生中起着重要作用。哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，分别位于不同的染色体上，由 9～11 个串联排列的基因组成。该基因是位于 2q31-2q37 染色体区域的几个同源框 HOXD 基因之一。移除整个 HOXD 基因簇或该簇 5' 端的缺失与严重的肢体和生殖器异常有关。该基因编码的蛋白质可能在细胞粘附过程的调节中发挥作用。[RefSeq 提供，2008 年 7 月]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]