2. Gene
  3. HPN - hepsin Gene

HPN - hepsin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肝蛋白酶

种属: Homo sapiens

同用名: TMPRSS1

基因 ID: 3249 | 基因类型: protein coding

关于 HPN

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:35,040,506-35,066,573 (from NCBI)

This gene has 11 transcripts (splice variants), 194 orthologues and 17 paralogues. Biased expression in liver (RPKM 53.7), kidney (RPKM 49.5) and 5 other tissues.

功能概要

该基因编码一种 II 型跨膜丝氨酸蛋白酶，该蛋白酶可能参与多种细胞功能，包括血液凝固和细胞形态的维持。编码蛋白的表达与癌症，尤其是前列腺癌的生长和进展有关。该蛋白质被切割成催化丝氨酸蛋白酶链和非催化清道夫受体富含半胱氨酸链，它们通过单个二硫键结合。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 1 月]

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate Cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

HPN 基因产物(4)

mRNA Protein Name
NM_001375441.3 NP_001362370.1 serine protease hepsin precursor
NM_001384133.1 NP_001371062.1 serine protease hepsin precursor
NM_002151.5 NP_002142.1 serine protease hepsin precursor
NM_182983.5 NP_892028.1 serine protease hepsin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables peptidase activity IDA
IDA: 通过直接分析推断
16908524 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15614436 GOA
enables serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
16908524 GOA
enables serine-type peptidase activity IDA
IDA: 通过直接分析推断
19911255 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in basement membrane disassembly IDA
IDA: 通过直接分析推断
16908524 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
15614436 GOA
involved in negative regulation of epithelial cell proliferation IDA
IDA: 通过直接分析推断
19843851 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
19843851 GOA
involved in positive regulation by host of viral transcription IDA
IDA: 通过直接分析推断
15614436 GOA
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
8346233 GOA
involved in positive regulation of hepatocyte proliferation IDA
IDA: 通过直接分析推断
15614436 GOA
involved in positive regulation of plasminogen activation IDA
IDA: 通过直接分析推断
16908524 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
16908524 GOA
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
8346233 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
8346233 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
17918732 GOA
located in membrane IDA
IDA: 通过直接分析推断
19843851 GOA
colocalizes with nuclear membrane IDA
IDA: 通过直接分析推断
15614436 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
1885621 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HPN 蛋白结构

Hepsin-SRCR

Hepsin-SRCR: Hepsin, SRCR (50 - 159)

Trypsin

Trypsin: Trypsin (163 - 400)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
蛋白主名 其他名称

serine protease hepsin

testicular tissue protein Li 85

HPN 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HPN P05981 SFTPC Homo sapiens P11686
Validated Y2H
32296183
种属内
HPN P05981 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HPN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77693 TMPRSS1/HPN Protein, Human (HEK293, His) P05981 (R45-L417) ≥95%

关联疾病

疾病名称 别名
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Prostatic Hyperplasia, Benign

Benign Prostatic Hyperplasia

BPH

Prostatic Hyperplasia
Deafness, Autosomal Recessive 39

DFNB39

Autosomal Recessive Nonsyndromic Deafness 39

Autosomal Recessive Deafness 39

Deafness, Autosomal Recessive, 39

Congenital Neurosensory Deafness Autosomal Recessive 39

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39

Deafness, Autosomal Recessive, Type 39
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B2087 Glycerol phenylbutyrate 99.81% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-135366 HPN-01 Inhibitor 98.61% Phase 1
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06342 HPN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus HPN VGNC VGNC:67639
Bos taurus HPN VGNC VGNC:29942
Mus musculus HPN MGD MGI:1196620
Canis familiaris HPN VGNC VGNC:41772
Rattus norvegicus HPN RGD RGD:61982
Macaca mulatta HPN VGNC VGNC:73513
Others HPN NCBI
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