APEH - acylaminoacyl-peptide hydrolase Gene

中文名称：酰氨酰肽水解酶

种属: Homo sapiens

同用名: APH; OPH; AARE; ACPH; D3S48E; D3F15S2; DNF15S2

关于 APEH

功能概要

该基因编码酰基肽水解酶，该酶催化优先从小乙酰化肽水解末端乙酰化氨基酸。由这种水解酶形成的乙酰氨基酸被氨酰化酶进一步加工成乙酸和游离氨基酸。该基因与氨基酰化酶基因位于 3 号染色体 (3p21) 的同一区域，该位点的缺失也与氨基酰化酶活性的降低有关。酰肽水解酶是一种 300 kDa 的同源四聚体蛋白，每个亚基由 732 个氨基酸残基组成。它可以在破坏活细胞中氧化受损的蛋白质方面发挥重要作用。该基因位点的缺失存在于各种类型的癌中，包括小细胞肺癌和肾细胞癌。[RefSeq 提供，2008 年 7 月]

This gene encodes the Enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated Peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008]