1. Gene
  2. IST1 - IST1 factor associated with ESCRT-III Gene

IST1 - IST1 factor associated with ESCRT-III Gene

中文名称:与 ESCRT-III 相关的 IST1 因子

种属: Homo sapiens

同用名: OLC1; CHMP8

基因 ID: 9798 | 基因类型: protein coding

关于 IST1

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,894,408-71,931,199 (from NCBI)

This gene has 27 transcripts (splice variants) and 218 orthologues. Ubiquitous expression in bone marrow (RPKM 49.3), gall bladder (RPKM 37.7) and 25 other tissues.

功能概要

该基因编码一种具有 MIT 相互作用基序的蛋白质,该基序与运输所需的内体分选复合物 (ESCRT) 的成分相互作用。 ESCRT 在囊泡出芽中发挥作用,例如胞质分裂中膜脱落过程中发生的作用。该基因在 19 号染色体上有一个假基因。已观察到该基因的编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2012 年 8 月]

This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

IST1 基因产物(6)

mRNA Protein Name
NM_001270975.2 NP_001257904.1 IST1 homolog isoform a
NM_001270976.1 NP_001257905.1 IST1 homolog isoform c
NM_001270977.2 NP_001257906.1 IST1 homolog isoform d
NM_001270978.2 NP_001257907.1 IST1 homolog isoform e
NM_001270979.1 NP_001257908.1 IST1 homolog isoform e
NM_014761.4 NP_055576.2 IST1 homolog isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables MIT domain binding IPI
IPI: 通过物理相互作用推断
19129479 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
19525971 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
20719964 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
19129479 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in abscission IDA
IDA: 通过直接分析推断
19129479 GOA
involved in abscission IMP
IMP: 通过突变表型推断
19525971 GOA
involved in cell division IMP
IMP: 通过突变表型推断
19129479 GOA
involved in cytoskeleton-dependent cytokinesis IMP
IMP: 通过突变表型推断
19525971 GOA
involved in establishment of protein localization IMP
IMP: 通过突变表型推断
23015756 GOA
involved in positive regulation of proteolysis IDA
IDA: 通过直接分析推断
20849418 GOA
involved in protein localization IMP
IMP: 通过突变表型推断
20719964 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Flemming body IDA
IDA: 通过直接分析推断
19129479 GOA
located in centrosome IDA
IDA: 通过直接分析推断
19129479 GOA
located in chromatin IDA
IDA: 通过直接分析推断
28242692 GOA
located in cytosol IDA
IDA: 通过直接分析推断
19129480 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
10942595 GOA
located in extracellular exosome IDA
IDA: 通过直接分析推断
21557262 GOA
located in midbody IDA
IDA: 通过直接分析推断
19129479 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IST1 蛋白结构

Ist1

Ist1: Regulator of Vps4 activity in the MVB pathway (25 - 190)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
蛋白主名 其他名称

IST1 homolog

IST1, ESCRT-III associated factor

IST1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IST1 P53990 CAPN7 Homo sapiens Q9Y6W3
Anti Tag CoIP
20849418
种属内
IST1 P53990 CAPN7 Homo sapiens Q9Y6W3
Pull Down
20849418
种属内
IST1 P53990 APEH Homo sapiens P13798
Y2H Prey Pooling
25416956
种属内
IST1 P53990 APEH Homo sapiens P13798
Validated Y2H
25416956
种属内
IST1 P53990 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
种属内
IST1 P53990 VPS9D1 Homo sapiens Q9Y2B5
Anti Tag CoIP
35271311
种属内
IST1 P53990 ATXN1 Homo sapiens P54253
Y2H Array
16713569
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gastric Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Stomach

Squamous Cell Carcinoma Of The Stomach

Spastic Paraplegia 20, Autosomal Recessive

Troyer Syndrome

SPG20

Spastic Paraparesis, Childhood-Onset, With Distal Muscle Wasting

Spastic Paraplegia, Autosomal Recessive, Troyer Type

Autosomal Recessive Spastic Paraplegia Type 20

Autosomal Recessive Hereditary Spastic Paraplegia

Spastic Paraplegia 20

Cross-Mckusick Syndrome

Autosomal Recessive Spastic Paraplegia 20

Autosomal Recessive Spastic Paraplegia Troyer Type

Childhood-Onset Spastic Paraparesis With Distal Muscle Wasting

Hereditary Spastic Paraplegia 20

Spastic Paraplegia Type 20

Hereditary Spastic Paraplegia

Childhood-Onset Spastic Paraparesis-Distal Muscle Wasting Syndrome

Spastic Paraparesis Childhood-Onset With Distal Muscle Wasting

Spastic Paraplegia Autosomal Recessive Troyer Type

Trs

Spastic Paraplegia Hereditary Autosomal Recessive

Spastic Paraplegia, Hereditary

Spastic Paraplegia 10, Autosomal Dominant

SPG10

Hereditary Spastic Paraplegia 10

Autosomal Dominant Spastic Paraplegia Type 10

Spastic Paraplegia 10

Spastic Paraplegia 10 With Or Without Peripheral Neuropathy

Autosomal Dominant Spastic Paraplegia 10

Autosomal Dominant Spastic Paraplegia

Spastic Paraplegia, Autosomal Dominant

Paraplegia, Spastic, Autosomal Dominant, Type 10

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

Zellweger Syndrome

Cerebrohepatorenal Syndrome

Zellweger Leukodystrophy

Zs

Congenital Iron Overload

Chr

Zws

Severe Pbd-Zsd

Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IST1 VGNC VGNC:73675
Canis familiaris IST1 VGNC VGNC:49862
Rattus norvegicus IST1 RGD RGD:1307799
Bos taurus IST1 VGNC VGNC:30304
Felis catus IST1 VGNC VGNC:62980
Mus musculus IST1 MGD MGI:1919205
Others IST1 NCBI