HES1 - hes family bHLH transcription factor 1 Gene

中文名称：hes 家族 bHLH 转录因子 1

种属: Homo sapiens

同用名: HHL; HRY; HES-1; bHLHb39

基因 ID: 3280 | 基因类型: protein coding

关于 HES1

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,136,148-194,138,732 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 12 paralogues. Ubiquitous expression in prostate (RPKM 46.7), thyroid (RPKM 44.9) and 24 other tissues.

功能概要

这种蛋白质属于转录因子的基本螺旋-环-螺旋家族。它是转录需要 bHLH 蛋白的基因的转录抑制因子。该蛋白质具有特定类型的基本结构域，其中包含与 N 盒而非典型 E 盒结合的螺旋中断蛋白。[RefSeq 提供，2008 年 7 月]

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

HES1 基因产物(1)

mRNA	Protein	Name
NM_005524.4	NP_005515.1	transcription factor HES-1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables histone deacetylase binding	IPI IPI: 通过物理相互作用推断	12535671	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12535671	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Notch signaling pathway	IDA IDA: 通过直接分析推断	16160079	GOA
involved in Notch signaling pathway	IMP IMP: 通过突变表型推断	19682396	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12535671	GOA
involved in negative regulation of pro-B cell differentiation	IMP IMP: 通过突变表型推断	12032823	GOA
involved in negative regulation of stem cell differentiation	IMP IMP: 通过突变表型推断	19682396	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12032823	GOA
involved in neuronal stem cell population maintenance	IEP IEP: 通过表达模式推断	19682396	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HES1 蛋白结构

HLH

Hairy_orange

0
100
200
280 a.a.

蛋白主名

其他名称

transcription factor HES-1

class B basic helix-loop-helix protein 39

HES1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HES1	Q14469	SIRT1	Homo sapiens	Q96EB6	Pull Down	12535671
种属内	HES1	Q14469	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	12535671

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Precursor T-Cell Acute Lymphoblastic Leukemia

T-All	Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma
Precursor T-Cell Acute Lymphocytic Leukemia	Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Adult T-Cell Lymphoma/Leukemia

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Chronic Cholangitis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-19369	L-685458		99.37%	否
HY-117113	JI051	Inhibitor	≥98.0%	否
HY-107245	Segetalin B		99.51%	否
HY-124484	JI130	Inhibitor	99.01%	否
HY-N13201	12-Deoxyphorbol 13-palmitate	Inducer	/	否
HY-164410	MO-I-1100	Inhibitor	/	否
HY-N3393	Lethedioside A		/	否
HY-RS06134	HES1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	HES1	VGNC	VGNC:102756
Rattus norvegicus	HES1	RGD	RGD:62081
Macaca mulatta	HES1	VGNC	VGNC:110360
Bos taurus	HES1	VGNC	VGNC:29818
Mus musculus	HES1	MGD	MGI:104853

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HES1 - hes family bHLH transcription factor 1 Gene

关于 HES1

功能概要

HES1 基因产物(1)

HES1 蛋白结构

HES1 蛋白互作信息

关联疾病

直系同源

热门区域

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HES1 - hes family bHLH transcription factor 1 Gene

关于 HES1

功能概要

HES1 基因产物(1)

HES1 蛋白结构

HES1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z