2. Neuronal Signaling Stem Cell/Wnt
  3. Notch
  4. MO-I-1100

MO-I-1100 是 ASPH (天冬氨酰-(天冬酰胺)-β-羟化酶)酶活性的抑制剂。MO-I-1100 可抑制 HCC 细胞迁移、侵袭和锚定非依赖性生长。MO-I-1100 通过抑制 HCC 中的 Notch 信号级联而表现出抗肿瘤作用。

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MO-I-1100 Chemical Structure

MO-I-1100 Chemical Structure

CAS No. : 1585217-40-8

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MO-I-1100 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MO-I-1100 is an inhibitor of ASPH (Aspartyl-(Asparaginyl)-β-hydroxylase) enzymatic activity. MO-I-1100 suppresses HCC cell migration, invasion and anchorage independent growth. MO-I-1100 shows antitumor effects through inhibiting Notch signaling cascade in HCC[1].

体外研究
(In Vitro)

MO-I-1100 对细胞表面缺乏 ASPH 的 NIH3T3 细胞的活力没有影响[1]。
MO-I-1100 (1-10 μM) 抑制 FOCUS 细胞的活力，该细胞具有高水平 ASPH 表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MO-I-1100 相关抗体:
体内研究
(In Vivo)

MO-I-100 (50 mg/kg，腹腔注射，每周连续 5 天，持续 2 周，然后每隔一天给药)可降低肝内原位异种移植 HCC 模型中的肿瘤生长[1]。
MO-I-1100 (50 mg/kg/天，腹腔注射，持续 5 天)可降低激活的 Notch 1（裂解片段）以及下游 HES1 和 HEY1 基因表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice with established s.c. tumor xenografts of FOCUS cells[1]
Dosage: 50 mg/kg/day
Administration: Ip, for 5 days
Result: Reduced the activated Notch 1 (cleaved fragment) as well as downstream HES1 and HEY1 gene expression.
分子量

379.81

Formula

C17H14ClNO5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MO-I-1100 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MO-I-11001585217-40-8NotchHepatocellular carcinomaHCCNIH3T3FOCUSβ-hydroxylaseASPHAspartyl-(Asparaginyl)-β-hydroxylaseHES1HEY1Inhibitorinhibitorinhibit

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