HSPA1B - heat shock protein family A (Hsp70) member 1B Gene

中文名称：热休克蛋白家族 A (Hsp70) 成员 1B

种属: Homo sapiens

同用名: HSP72; HSPA1; HSX70; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1B

关于 HSPA1B

功能概要

这个无内含子的基因编码一个 70kDa 的热休克蛋白，它是热休克蛋白 70 家族的一员。与其他热休克蛋白结合，该蛋白稳定现有蛋白以防止聚集，并介导新翻译蛋白在胞质溶胶和细胞器中的折叠。它还通过与富含 AU 的元素 RNA 结合蛋白 1 的相互作用参与泛素-蛋白酶体途径。该基因位于主要组织相容性复合体 III 类区域，与两个编码相似蛋白质的密切相关基因位于一个簇中。[RefSeq 提供，2008 年 7 月]

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]