2. Gene
  3. Cecr2 - CECR2, histone acetyl-lysine reader Gene

Cecr2 - CECR2, histone acetyl-lysine reader Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：CECR2 ，组蛋白乙酰赖氨酸阅读器

种属: Mus musculus

同用名: Gtl4; 2610101O16Rik; 2810409N01Rik

基因 ID: 330409 | 基因类型: protein coding

关于 Cecr2

Chromosome 6: 120,643,330-120,748,151 forward strand.GRCm39:CM000999.3

This gene has 8 transcripts (splice variants), 156 orthologues, 11 paralogues and is associated with 24 phenotypes. Ubiquitous expression in testis adult (RPKM 4.5), CNS E11.5 (RPKM 4.) and 23 other tissues.

功能概要

预测该基因编码的蛋白可启动 ATP 依赖性染色质重塑活性。作用于内耳发育的上游或内耳发育；初级神经管形成；和单一施肥。位于常染色质中。 ISWI 型复合体的一部分。以多种结构表达，包括胚外成分；泌尿生殖系统；和嗅觉上皮。用于研究无脑畸形。与人类 CECR2（CECR2 组蛋白乙酰赖氨酸读取器）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP-dependent chromatin remodeler activity. Acts upstream of or within inner ear development; primary neural tube formation; and single fertilization. Located in euchromatin. Part of ISWI-type complex. Is expressed in several structures, including extraembryonic component; genitourinary system; and olfactory epithelium. Used to study anencephaly. Orthologous to human CECR2 (CECR2 histone acetyl-lysine reader). [provided by Alliance of Genome Resources, Apr 2022]

Cecr2 基因产物(2)

mRNA Protein Name
NM_001368706.1 NP_001355635.1 chromatin remodeling regulator CECR2 isoform 2
NM_001128151.2 NP_001121623.1 chromatin remodeling regulator CECR2 isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cochlea development IMP
IMP: 通过突变表型推断
21246654 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: 通过突变表型推断
21246654 MGI
acts upstream of or within neural fold formation IMP
IMP: 通过突变表型推断
21246654 MGI
acts upstream of or within neural tube closure IGI
IGI: 通过遗传相互作用推断
21246654 MGI
acts upstream of or within neural tube closure IMP
IMP: 通过突变表型推断
15640247 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
22045912 MGI
acts upstream of or within single fertilization IMP
IMP: 通过突变表型推断
22154806 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ISWI-type complex IPI
IPI: 通过物理相互作用推断
22154806 MGI
located in euchromatin IDA
IDA: 通过直接分析推断
9701556 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cecr2 蛋白结构

Bromo_gcn5_like

Bromo_gcn5_like: cd05509 (417 - 517)

PHA03247

PHA03247: cl33720 (557 - 1030)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1453 a.a.
蛋白主名 其他名称

chromatin remodeling regulator CECR2

cat eye syndrome critical region protein 2 homolog

cat eye syndrome chromosome region, candidate 2 homolog

gene trap locus 4

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110374 NVS-CECR2-1 Inhibitor 99.40% 否
HY-112610 CF53 Inhibitor 99.78% 否
HY-114205A TP-238 hydrochloride Inhibitor ≥99.0% 否
HY-114205 TP-238 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cecr2 NCBI NCBI:27443
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