IARS1 - isoleucyl-tRNA synthetase 1 Gene

种属: Homo sapiens (human)

同用名: IRS; IARS; ILRS; ILERS; GRIDHH; PRO0785

关于 IARS1

功能概要

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking Amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I Aminoacyl-tRNA Synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]