2. Gene
  3. UBAC2 - UBA domain containing 2 Gene

UBAC2 - UBA domain containing 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 UBA 域 2

种属: Homo sapiens

同用名: PHGDHL1

基因 ID: 337867 | 基因类型: protein coding

关于 UBAC2

This gene has 11 transcripts (splice variants), 201 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 8.2), thyroid (RPKM 7.2) and 25 other tissues.

功能概要

参与经典 Wnt 信号通路的负调节和蛋白质逆行转运、ER 到胞质溶胶的负调节。作用于内质网蛋白质定位的上游或内部。位于内质网。 [由基因组资源联盟提供，2022 年 4 月]

Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of retrograde protein transport, ER to cytosol. Acts upstream of or within protein localization to endoplasmic reticulum. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

UBAC2 基因产物(2)

mRNA Protein Name
NM_001144072.2 NP_001137544.1 ubiquitin-associated domain-containing protein 2 isoform 1 precursor
NM_177967.4 NP_808882.1 ubiquitin-associated domain-containing protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22119785 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
31073040 GOA
involved in negative regulation of retrograde protein transport, ER to cytosol IMP
IMP: 通过突变表型推断
25660456 GOA
acts upstream of or within protein localization to endoplasmic reticulum IDA
IDA: 通过直接分析推断
23297223 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23297223 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UBAC2 蛋白结构

UBA

UBA: UBA/TS-N domain (306 - 341)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
蛋白主名 其他名称

ubiquitin-associated domain-containing protein 2

RP11-178C10.1

UBAC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UBAC2 Q8NBM4 FAF2 Homo sapiens Q96CS3
Pull Down
22119785
Intra UBAC2 Q8NBM4 FAF2 Homo sapiens Q96CS3
Anti Bait CoIP
22119785
Intra UBAC2 Q8NBM4 FAF2 Homo sapiens Q96CS3
Anti Tag CoIP
28514442
Intra UBAC2 Q8NBM4 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Hypopyon
Photoallergic Dermatitis

Dermatitis, Photoallergic

Photoallergic Contact Dermatitis

Photoallergic Eczema

Photo-Allergic Contact Eczema
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15327 UBAC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus UBAC2 VGNC VGNC:102355
Rattus norvegicus UBAC2 RGD RGD:1311689
Macaca mulatta UBAC2 VGNC VGNC:106308
Bos taurus UBAC2 VGNC VGNC:36568
Canis familiaris UBAC2 VGNC VGNC:48043
Mus musculus UBAC2 MGD MGI:1916139
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