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  2. ANO9 - anoctamin 9 Gene

ANO9 - anoctamin 9 Gene

中文名称:茴香胺 9

种属: Homo sapiens

同用名: PIG5; TP53I5; TMEM16J

基因 ID: 338440 | 基因类型: protein coding

关于 ANO9

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:417,938-442,011 (from NCBI)

This gene has 8 transcripts (splice variants), 253 orthologues and 10 paralogues. Broad expression in skin (RPKM 19.3), duodenum (RPKM 19.0) and 14 other tissues.

功能概要

由该基因编码的蛋白质是 TMEM16 (anoctamin) 蛋白质家族的成员,其中一些形成完整的膜钙激活氯离子通道。编码蛋白的功能尚未阐明,尽管它可能具有通道形成能力,也可能具有磷脂加扰酶活性。已观察到该基因在 II 期和 III 期结直肠癌中上调。[RefSeq 提供,2016 年 12 月]

The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]

ANO9 基因产物(2)

mRNA Protein Name
NM_001012302.3 NP_001012302.2 anoctamin-9 isoform 1
NM_001347882.2 NP_001334811.1 anoctamin-9 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel activity IMP
IMP: 通过突变表型推断
36520003 GOA
enables channel activity IDA
IDA: 通过直接分析推断
29604966 GOA
enables chloride channel inhibitor activity IDA
IDA: 通过直接分析推断
22946059 GOA
NOT enables intracellularly calcium-gated chloride channel activity IDA
IDA: 通过直接分析推断
21984732 GOA
enables intracellularly calcium-gated chloride channel activity IMP
IMP: 通过突变表型推断
22946059 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21525870 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chloride transmembrane transport IMP
IMP: 通过突变表型推断
22946059 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
36520003 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22946059 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ANO9 蛋白结构

Anoctamin

Anoctamin: Calcium-activated chloride channel (179 - 739)

  • 0
  • 200
  • 400
  • 600
  • 782 a.a.
蛋白主名 其他名称

anoctamin-9

p53-induced gene 5 protein

ANO9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ANO9 A1A5B4 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属内
ANO9 A1A5B4 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属内
ANO9 A1A5B4 PLEKHF2 Homo sapiens Q9H8W4 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Scott Syndrome

SCTS

Bdplt7

Prothrombin Consumption Deficiency

Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X

Bleeding Disorder, Platelet-Type, 7

Prothrombin Conversion Defect, Familial

Prothrombin Consumption Inhibitor, Familial

Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X

Familial Prothrombin Consumption Inhibitor

Familial Prothrombin Conversion Defect

Platelet-Type Bleeding Disorder 7

Platelet Factor X Receptor Deficiency

Bleeding Disorder Platelet-Type 7

Prothrombin Consumption Inhibitor Familial

Prothrombin Conversion Defect Familial

Gnathodiaphyseal Dysplasia

GDD

Osteogenesis Imperfecta With Unusual Skeletal Lesions

Gnathodiaphyseal Sclerosis

Osteogenesis Imperfecta, Levin Type

Levin Syndrome 2

Dysplasia, Gnathodiaphyseal

Spinocerebellar Ataxia, Autosomal Recessive 10

SCAR10

Autosomal Recessive Spinocerebellar Ataxia 10

Adult-Onset Autosomal Recessive Cerebellar Ataxia

Autosomal Recessive Spinocerebellar Ataxia Type 10

Spinocerebellar Ataxia, Autosomal Recessive, 10

Ataxia, Spinocerebellar, Autosomal Recessive, Type 10

Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10

SCA10

Spinocerebellar Ataxia-10

Ataxia, Spinocerebellar, Type 10

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ANO9 RGD RGD:1560565
Bos taurus ANO9 VGNC VGNC:106640
Mus musculus ANO9 MGD MGI:1918595
Canis familiaris ANO9 VGNC VGNC:37931
Felis catus ANO9 VGNC VGNC:59834