2. Gene
  3. Gpbar1 - G protein-coupled bile acid receptor 1 Gene

Gpbar1 - G protein-coupled bile acid receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联胆汁酸受体 1

种属: Rattus norvegicus

同用名: Tgr5; M-BAR

基因 ID: 338443 | 基因类型: protein coding

关于 Gpbar1

Primary_assembly 9: 75,860,677-75,863,168 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 75 orthologues and is associated with 12 phenotypes. Biased expression in Kidney (RPKM 11.), Lung (RPKM 9.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联受体活性。参与 ERK1 和 ERK2 级联的正调控和胆管细胞增殖的正调控。预测位于细胞质和质膜。预计是受体复合体的一部分。非酒精性脂肪性肝炎和多囊肾病的生物标志物。与人类 GPBAR1（G 蛋白偶联胆汁酸受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of cholangiocyte proliferation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of receptor complex. Biomarker of non-alcoholic steatohepatitis and polycystic kidney disease. Orthologous to human GPBAR1 (G protein-coupled Bile Acid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gpbar1 基因产物(2)

mRNA Protein Name
NM_177936.2 NP_808797.1 G-protein coupled bile acid receptor 1
NM_177936.2 NP_808797.1 G-protein coupled bile acid receptor 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
12524422 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
28543567 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
28543567 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: 通过突变表型推断
28543567 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: 通过突变表型推断
28543567 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Gpbar1 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (18 - 282)

7tm_GPCRs

7tm_GPCRs: cd14964 (18 - 39)

7tm_GPCRs

7tm_GPCRs: cd14964 (49 - 70)

7tm_GPCRs

7tm_GPCRs: cd14964 (84 - 106)

7tm_GPCRs

7tm_GPCRs: cd14964 (124 - 140)

7tm_GPCRs

7tm_GPCRs: cd14964 (160 - 183)

7tm_GPCRs

7tm_GPCRs: cd14964 (221 - 243)

7tm_GPCRs

7tm_GPCRs: cd14964 (257 - 282)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
蛋白主名 其他名称

G-protein coupled bile acid receptor 1

G protein-coupled receptor

membrane-type receptor for bile acids

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101274 BAR501 Agonist ≥98.0% 否
HY-101273 BAR502 Agonist 99.53% 否
HY-147086 CAY10789 99.84% 否
HY-145234 GPBAR1-IN-3 / 否
HY-107612 GPBAR-A Agonist / 否
HY-146453 TGR5 Receptor Agonist 3 Agonist / 否
HY-RS05622 GPBAR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05623 Gpbar1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05624 Gpbar1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-165155 CysLT1 receptor antagonist-1 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpbar1 NCBI NCBI:151306
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