1. Gene
  2. ICAM3 - intercellular adhesion molecule 3 Gene

ICAM3 - intercellular adhesion molecule 3 Gene

中文名称:细胞间粘附分子 3

种属: Homo sapiens

同用名: CD50; CDW50; ICAM-R

基因 ID: 3385 | 基因类型: protein coding

关于 ICAM3

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,333,776-10,339,624 (from NCBI)

This gene has 10 transcripts (splice variants), 452 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 55.9), spleen (RPKM 28.5) and 12 other tissues.

功能概要

该基因编码的蛋白质是细胞间粘附分子 (ICAM) 家族的成员。所有 ICAM 蛋白都是 I 型跨膜糖蛋白,包含 2-9 个免疫球蛋白样 C2 型结构域,并与白细胞粘附 LFA-1 蛋白结合。该蛋白由所有白细胞组成型且大量表达,并且可能是 LFA-1 在免疫反应启动中最重要的配体。它不仅充当粘附分子,而且充当有效的信号分子。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2016 年 2 月]

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2016]

ICAM3 基因产物(7)

mRNA Protein Name
NM_001320605.2 NP_001307534.1 intercellular adhesion molecule 3 isoform 2 precursor
NM_001320606.2 NP_001307535.1 intercellular adhesion molecule 3 isoform 3
NM_001320608.2 NP_001307537.1 intercellular adhesion molecule 3 isoform 4
NM_001395374.1 NP_001382303.1 intercellular adhesion molecule 3 isoform 5
NM_001395375.1 NP_001382304.1 intercellular adhesion molecule 3 isoform 6
NM_001395376.1 NP_001382305.1 intercellular adhesion molecule 3 isoform 7
NM_002162.5 NP_002153.2 intercellular adhesion molecule 3 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
1448173 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12082081 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ICAM3 蛋白结构

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (31 - 119)

Ig_2

Ig_2: Immunoglobulin domain (130 - 193)

Ig_2

Ig_2: Immunoglobulin domain (317 - 395)

Ig_3

Ig_3: Immunoglobulin domain (404 - 466)

  • 0
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  • 500
  • 547 a.a.
蛋白主名 其他名称

intercellular adhesion molecule 3

ICAM-3

ICAM3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ICAM3 P32942 EDDM3B Homo sapiens P56851 32296183
种属内
ICAM3 P32942 NINJ2 Homo sapiens Q9NZG7 32296183
种属内
ICAM3 P32942 BRICD5 Homo sapiens Q6PL45-2 32296183
种属内
ICAM3 P32942 CLDN19 Homo sapiens Q8N6F1-2 32296183
种属内
ICAM3 P32942 SMCO4 Homo sapiens Q9NRQ5 32296183
种属内
ICAM3 P32942 SEC22A Homo sapiens Q96IW7 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 ICAM3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72921 ICAM-3/CD50 Protein, Human (HEK293, His) P32942 (Q30-H485) ≥95%
HY-P74872 ICAM-3/CD50 Protein, Human (HEK293, His-Fc) P32942 (Q30-H485) ≥95%

ICAM3 抗体

目录号 产品名 应用 反应物种
HY-P81571 CD50 Antibody (YA1316) IHC-P, ICC/IF, FC Human
HY-P83264 ICAM3 Antibody (YA3009) WB, IHC-P, IP Human, Rat

关联疾病

疾病名称 别名
Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms

Relapsing Remitting Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Rrms

Multiple Sclerosis Relapsing-Remitting

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon

Stage 0 Colonic Carcinoma

Stage 0 Carcinoma Of Colon

Intraepithelial Neoplasia Of Colon, High Grade

Carcinoma In Situ Of Cecum

Carcinoma In Situ Of Hepatic Flexure

Carcinoma In Situ Of Ileocecal Valve

Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ
Polyarteritis Nodosa

Polyarteritis

Periarteritis Nodosa

Pan

Periarteritis

Kussmaul-Maier Disease

Panarteritis Nodosa

Kussmaul Disease

Pan - [Polyarteritis Nodosa]

Polyangiitis

Panangiitis

Arteritis Nodosa

Funisitis
Dengue Shock Syndrome

Dss

Dengue Hemorrhagic Fever

Severe Dengue

Dengue Haemorrhagic Fever

Dhf

Severe Dengue Haemorrhagic Fever

Severe Dengue Fever

Dengue Shock Syndrome

Immune Deficiency Disease

Immunodeficiency

Primary Immunodeficiency

Primary Immunodeficiency Disease

Immunologic Deficiency Syndromes

Hypoimmunity

Immune Deficiency Disorder

Immunodeficiency Syndrome

Immune Disorder

Primary Immune Deficiency Disorder

Immune System Diseases

Human Immunodeficiency Virus Infection

Hiv - [Human Immunodeficiency Virus Infection]

Hiv Positive Nos

Hiv Disease

Acquired Immune Deficiency Syndrome-Related Complex

Aids-Like Syndrome

Aids-Related Complex Nos

Arc - [Aids-Related Complex]

Immunodeficiency Due To Human Immunodeficiency Virus Infection

Unspecified Human Immunodeficiency Virus Disease

Hiv Disease Nos

Human Immunodeficiency Virus Positive Nos

Hiv Nos

Deficiency Of Complement Initial Pathway

Deficiency Of Complement Terminal Pathway

Cfdd - [Complement Factor D Deficiency]

Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

Nonfamilial Hypogammaglobulinaemia

Common Variable Immune Deficiency

Nonfamilial Agammaglobulinaemia

Common Variable Agammaglobulinaemia

Agammaglobulinaemia Nos

Agammaglobulinaemia Antibody Deficiency Syndrome

Hypogammaglobulinaemia Antibody Deficiency Syndrome

Acquired Agammaglobulinaemia Nos

Hypogammaglobulinaemia Nos

Hyper Igm

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma