IFI16 - interferon gamma inducible protein 16 Gene

中文名称：干扰素γ诱导蛋白 16

种属: Homo sapiens

同用名: PYHIN2; IFNGIP1

基因 ID: 3428 | 基因类型: protein coding

关于 IFI16

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,999,976-159,055,151 (from NCBI)

This gene has 13 transcripts (splice variants), 52 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 45.3), appendix (RPKM 41.3) and 24 other tissues.

功能概要

该基因编码 HIN-200 (具有 200 个氨基酸重复的造血干扰素诱导核抗原) 细胞因子家族的成员。编码的蛋白质包含涉及 DNA 结合、转录调节和蛋白质-蛋白质相互作用的结构域。该蛋白定位于核质和核仁，并与 p53 和 retinoblastoma-1 相互作用。它调节 p53 功能，并抑制 Ras/Raf 信号通路中的细胞生长。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 4 月]

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

IFI16 基因产物(8)

mRNA	Protein	Name
NM_001206567.2	NP_001193496.1	gamma-interferon-inducible protein 16 isoform 1
NM_001364867.2	NP_001351796.1	gamma-interferon-inducible protein 16 isoform 3
NM_001376587.1	NP_001363516.1	gamma-interferon-inducible protein 16 isoform 3
NM_001376588.1	NP_001363517.1	gamma-interferon-inducible protein 16 isoform 2
NM_001376589.1	NP_001363518.1	gamma-interferon-inducible protein 16 isoform 2
NM_001376591.1	NP_001363520.1	gamma-interferon-inducible protein 16 isoform 4
NM_001376592.1	NP_001363521.1	gamma-interferon-inducible protein 16 isoform 4
NM_005531.3	NP_005522.2	gamma-interferon-inducible protein 16 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables double-stranded DNA binding	IDA IDA: 通过直接分析推断	7536752	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	9718316	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11146555	GOA
enables transcription factor binding	IDA IDA: 通过直接分析推断	12894224	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of cysteine-type endopeptidase activity	IMP IMP: 通过突变表型推断	21575908	GOA
involved in activation of innate immune response	IDA IDA: 通过直接分析推断	21575908	GOA
involved in cellular response to glucose starvation	IDA IDA: 通过直接分析推断	21573174	GOA
involved in cellular response to ionizing radiation	IDA IDA: 通过直接分析推断	14654789	GOA
involved in defense response to virus	IDA IDA: 通过直接分析推断	21478870	GOA
involved in defense response to virus	IMP IMP: 通过突变表型推断	21575908	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: 通过突变表型推断	21573174	GOA
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: 通过直接分析推断	14654789	GOA
involved in monocyte differentiation	IDA IDA: 通过直接分析推断	9766636	GOA
involved in negative regulation of AIM2 inflammasome complex assembly	IDA IDA: 通过直接分析推断	30104205	GOA
involved in negative regulation of DNA binding	IDA IDA: 通过直接分析推断	22291595	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	9642285	GOA
involved in negative regulation of cysteine-type endopeptidase activity	IDA IDA: 通过直接分析推断	22046441	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: 通过突变表型推断	24413532	GOA
involved in negative regulation of innate immune response	IDA IDA: 通过直接分析推断	22046441	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	12894224	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	22046441	GOA
involved in negative regulation of viral genome replication	IDA IDA: 通过直接分析推断	22291595	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: 通过直接分析推断	21575908	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	11146555	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	21575908	GOA
involved in regulation of autophagy	IEP IEP: 通过表达模式推断	21573174	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	30104205	GOA
colocalizes with cytosol	IPI IPI: 通过物理相互作用推断	24531343	GOA
located in nuclear speck	IDA IDA: 通过直接分析推断	19158679	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	14654789	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	14654789	GOA
located in nucleus	IDA IDA: 通过直接分析推断	7536752	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFI16 蛋白结构

PYRIN

HIN

0
200
400
600
785 a.a.

蛋白主名

其他名称

gamma-interferon-inducible protein 16

interferon-gamma induced protein IFI 16

IFI16 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Confocal	14654789
种属内	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	14654789
种属内	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Pull Down	14654789
种属内	IFI16	Q16666	AR	Homo sapiens	P10275	Anti Bait CoIP	16494870
种属内	IFI16	Q16666	AR	Homo sapiens	P10275	Pull Down	16494870
种属内	IFI16	Q16666	DHX58	Homo sapiens	Q96C10	Pull Down	30833792

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Sting-Associated Vasculopathy With Onset In Infancy

Savi	Sting-Associated Vasculopathy, Infantile Onset
Sting-Associated Vasculopathy, Infantile-Onset

Genital Herpes

Herpes Genitalis	Genital Herpes Simplex
Venereal Herpes	Virus-Genital Herpes

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	否
HY-RS06552	IFI16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	IFI16	VGNC	VGNC:73562
Others	IFI16	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IFI16 - interferon gamma inducible protein 16 Gene

关于 IFI16

功能概要

IFI16 基因产物(8)

IFI16 蛋白结构

IFI16 蛋白互作信息

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

IFI16 - interferon gamma inducible protein 16 Gene

关于 IFI16

功能概要

IFI16 基因产物(8)

IFI16 蛋白结构

IFI16 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z